Title |
Contribution of the PD-L1/PD-1 pathway to T-cell exhaustion: an update on implications for chronic infections and tumor evasion
|
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Published in |
Cancer Immunology, Immunotherapy, December 2006
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DOI | 10.1007/s00262-006-0272-1 |
Pubmed ID | |
Authors |
Christian Blank, Andreas Mackensen |
Abstract |
Recent clinical data support ideas of Programmed death receptor-ligand 1 (PD-L1; also called B7-H1, CD274) playing an important role in immune evasion of tumor cells. Expression of PD-L1 on tumors strongly correlates with the survival of cancer patients. PD-L1 on tumors interacts with the co-inhibitory molecule Programmed death receptor-1 (PD-1, CD279) on T cells mediating decreased TCR-mediated proliferation and cytokine production. In animal tumor models, blockade of PD-L1/PD-1 interactions resulted in an improved tumor control. In addition, exhausted T cells during chronic viral infections could be revived by PD-L1 blockade. Thus, targeting PD-L1/PD-1 interactions might improve the efficacy of adoptive cell therapies (ACT) of chronic infections as well as cancers. Obstacles for a general blockade of PD-L1 might be its role in mediating peripheral tolerance. This review discusses the currently available data concerning the role of PD-L1 in tumor immune evasion and envisions possibilities for implementation into ACT for cancer patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
France | 1 | 33% |
Unknown | 2 | 67% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 3 | 1% |
Japan | 2 | <1% |
Korea, Republic of | 1 | <1% |
Colombia | 1 | <1% |
Switzerland | 1 | <1% |
India | 1 | <1% |
Unknown | 275 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 44 | 15% |
Student > Ph. D. Student | 43 | 15% |
Student > Bachelor | 39 | 14% |
Student > Master | 38 | 13% |
Student > Doctoral Student | 17 | 6% |
Other | 41 | 14% |
Unknown | 62 | 22% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 82 | 29% |
Agricultural and Biological Sciences | 54 | 19% |
Biochemistry, Genetics and Molecular Biology | 27 | 10% |
Immunology and Microbiology | 25 | 9% |
Chemistry | 12 | 4% |
Other | 19 | 7% |
Unknown | 65 | 23% |