| Title |
Eosinophils, ribonucleases and host defense: Solving the puzzle
|
|---|---|
| Published in |
Immunologic Research, November 1999
|
| DOI | 10.1007/bf02790409 |
| Pubmed ID | |
| Authors |
Helene F. Rosenberg, Joseph B. Domachowske |
| Abstract |
The eosinophil ribonucleases eosinophil-derived neurotoxin (EDN/RNase 2) and eosinophil cationic protein (ECP/RNase 3) are among the major secretory effector proteins of human eosinophilic leukocytes, cells whose role in host defense remains controversial and poorly understood. We have recently described the unusual manner in which this ribonuclease lineage has evolved, with extraordinary diversification observed in primate as well as in rodent EDNs and ECPs. The results of our evolutionary studies suggest that the EDN/ ECP ribonucleases are in the process of being tailored for a specific, ribonuclease-related goal. With this in mind, we have begun to look carefully at some of the intriguing associations that link eosinophils and their ribonucleases to disease caused by the single-stranded RNA viral pathogen, respiratory syncytial virus (RSV). Recent work in our laboratory has demonstrated that eosinophils can mediate a direct, ribonuclease-dependent reduction in infectivity of RSV in vitro, and that EDN can function alone as an independent antiviral agent. The results of this work have led us to consider the possibility that the EDN/ECP ribonucleases represent a heretofore unrecognized element of innate and specific antiviral host defense. |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 20% |
| Other | 4 | 13% |
| Researcher | 4 | 13% |
| Student > Master | 3 | 10% |
| Professor | 2 | 7% |
| Other | 3 | 10% |
| Unknown | 8 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 6 | 20% |
| Agricultural and Biological Sciences | 5 | 17% |
| Immunology and Microbiology | 4 | 13% |
| Medicine and Dentistry | 2 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 2 | 7% |
| Unknown | 10 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 February 2019.
All research outputs
#7,453,827
of 22,787,797 outputs
Outputs from Immunologic Research
#277
of 904 outputs
Outputs of similar age
#11,135
of 36,131 outputs
Outputs of similar age from Immunologic Research
#2
of 7 outputs
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