Title |
Absence of chronic hepatitis E virus infection in liver transplant recipients: Report from a hyperendemic region
|
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Published in |
Indian Journal of Gastroenterology, March 2018
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DOI | 10.1007/s12664-018-0840-2 |
Pubmed ID | |
Authors |
Pragya Agarwala, Ekta Gupta, Manish Chandra Choudhary, Viniyendra Pamecha |
Abstract |
Most cases of chronic hepatitis E virus (HEV) infection in solid organ transplant recipients are attributable to genotype 3. Although India is hyperendemic for HEV genotype 1, chronic infection in transplant patients has not been reported. In this study, 30 liver transplant recipients were followed up by systematic testing for various markers of HEV (IgM, IgG, HEV-Ag, and RNA) on blood and stool samples obtained pre-transplant, and then at 3 and 6 months post-transplant to look for HEV exposure and persistence. Evidence of HEV infection was found in 6 (20%) cases post-transplant but none of the recipients demonstrated active viremia or antigenemia. This suggests that the circulating genotype of HEV in our population might have limited potential to cause chronic infections. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 29% |
Student > Bachelor | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Student > Master | 2 | 12% |
Lecturer | 1 | 6% |
Other | 0 | 0% |
Unknown | 5 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 41% |
Biochemistry, Genetics and Molecular Biology | 1 | 6% |
Veterinary Science and Veterinary Medicine | 1 | 6% |
Unknown | 8 | 47% |