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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Proline Isomerization of Histone H3 Regulates Lysine Methylation and Gene Expression
|
|---|---|
| Published in |
Cell, September 2006
|
| DOI | 10.1016/j.cell.2006.07.026 |
| Pubmed ID | |
| Authors |
Christopher J. Nelson, Helena Santos-Rosa, Tony Kouzarides |
| Abstract |
The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 proline P30 and P38 in vitro. We show that P38 is necessary for methylation of K36 and that isomerization by Fpr4 inhibits the ability of Set2 to methylate H3 K36 in vitro. These results suggest that the conformational state of P38, controlled by Fpr4, is important for methylation of H3K36 by Set2. Consistent with such an antagonistic role, abrogation of Fpr4 catalytic activity in vivo results in increased levels of H3K36 methylation and delayed transcriptional induction kinetics of specific genes in yeast. These results identify proline isomerization as a novel noncovalent histone modification that regulates transcription and provides evidence for crosstalk between histone lysine methylation and proline isomerization. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 305 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 5 | 2% |
| United States | 5 | 2% |
| Norway | 1 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Switzerland | 1 | <1% |
| India | 1 | <1% |
| France | 1 | <1% |
| Belgium | 1 | <1% |
| Other | 1 | <1% |
| Unknown | 287 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 78 | 26% |
| Researcher | 63 | 21% |
| Student > Bachelor | 33 | 11% |
| Student > Master | 25 | 8% |
| Professor > Associate Professor | 18 | 6% |
| Other | 45 | 15% |
| Unknown | 43 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 134 | 44% |
| Biochemistry, Genetics and Molecular Biology | 77 | 25% |
| Chemistry | 21 | 7% |
| Medicine and Dentistry | 10 | 3% |
| Immunology and Microbiology | 4 | 1% |
| Other | 15 | 5% |
| Unknown | 44 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 November 2022.
All research outputs
#2,475,138
of 25,373,627 outputs
Outputs from Cell
#6,211
of 17,169 outputs
Outputs of similar age
#5,342
of 89,587 outputs
Outputs of similar age from Cell
#21
of 90 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one has gotten more attention than average, scoring higher than 63% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 89,587 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 90 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.