| Title |
A genetic reduction in the serotonin transporter differentially influences MDMA and heroin induced behaviours
|
|---|---|
| Published in |
Psychopharmacology, March 2018
|
| DOI | 10.1007/s00213-018-4880-1 |
| Pubmed ID | |
| Authors |
Bridget W. Brox, Bart A. Ellenbroek |
| Abstract |
Despite ongoing study and research to better understand drug addiction, it continues to be a heavy burden. Only a small percentage of individuals who take drugs of abuse go on to develop addiction. However, there is growing evidence to suggest that a reduction in the serotonin transporter may play an important role for those that transition to compulsive drug taking. Studies have demonstrated that reduced serotonin transporter function potentiates self-administration of psychostimulant drugs ("ecstasy," MDMA; cocaine); however, additional research revealed no differences between genotypes when the opioid heroin was self-administered. These results suggest that a reduction in the serotonin transporter may confer susceptibility to the development of addiction to some classes of drugs but not others. Importantly, the mechanism underlying facilitated psychostimulant self-administration is currently unknown. Therefore, to continue investigating the relationship between compromised serotonergic function and different classes of drugs, a series of experiments was conducted investigating locomotor activity (LMA) and conditioned taste aversion (CTA) in the serotonin transporter knockout (SERT KO) rat model. MDMA-induced hyperactivity was reduced, while MDMA-induced CTA was enhanced, in SERT KO rats. However, there were no genotype differences in heroin-induced behaviours. These results reinforce the idea that a reduction in the serotonin transporter drives differential effects between disparate classes of drugs of abuse. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 5 | 22% |
| Researcher | 3 | 13% |
| Lecturer > Senior Lecturer | 1 | 4% |
| Professor | 1 | 4% |
| Lecturer | 1 | 4% |
| Other | 2 | 9% |
| Unknown | 10 | 43% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 17% |
| Psychology | 4 | 17% |
| Neuroscience | 2 | 9% |
| Medicine and Dentistry | 2 | 9% |
| Physics and Astronomy | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 10 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2019.
All research outputs
#20,734,513
of 23,335,153 outputs
Outputs from Psychopharmacology
#4,983
of 5,396 outputs
Outputs of similar age
#294,529
of 333,254 outputs
Outputs of similar age from Psychopharmacology
#38
of 43 outputs
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