| Title |
Tight Junctions of the Blood–Brain Barrier
|
|---|---|
| Published in |
Cellular and Molecular Neurobiology, February 2000
|
| DOI | 10.1023/a:1006995910836 |
| Pubmed ID | |
| Authors |
Uwe Kniesel, Hartwig Wolburg |
| Abstract |
1. The blood-brain barrier is essential for the maintenance and regulation of the neural microenvironment. The blood-brain barrier endothelial cells comprise an extremely low rate of transcytotic vesicles and a restrictive paracellular diffusion barrier. The latter is realized by the tight junctions between the endothelial cells of the brain microvasculature, which are subject of this review. Morphologically, blood-brain barrier-tight junctions are more similar to epithelial tight junctions than to endothelial tight junctions in peripheral blood vessels. 2. Although blood-brain barrier-tight junctions share many characteristics with epithelial tight junctions, there are also essential differences. However, in contrast to tight junctions in epithelial systems, structural and functional characteristics of tight junctions in endothelial cells are highly sensitive to ambient factors. 3. Many ubiquitous molecular constituents of tight junctions have been identified and characterized including claudins, occludin, ZO-1, ZO-2, ZO-3, cingulin, and 7H6. Signaling pathways involved in tight junction regulation comprise, among others, G-proteins, serine, threonine, and tyrosine kinases, extra- and intracellular calcium levels, cAMP levels, proteases, and TNF alpha. Common to most of these pathways is the modulation of cytoskeletal elements which may define blood-brain barrier characteristics. Additionally, cross-talk between components of the tight junction- and the cadherin-catenin system suggests a close functional interdependence of the two cell-cell contact systems. 4. Recent studies were able to elucidate crucial aspects of the molecular basis of tight junction regulation. An integration of new results into previous morphological work is the central intention of this review. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 1% |
| Germany | 1 | 1% |
| Canada | 1 | 1% |
| Unknown | 77 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 18% |
| Student > Bachelor | 12 | 15% |
| Researcher | 11 | 14% |
| Student > Master | 10 | 13% |
| Student > Doctoral Student | 6 | 8% |
| Other | 6 | 8% |
| Unknown | 21 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 11 | 14% |
| Medicine and Dentistry | 11 | 14% |
| Agricultural and Biological Sciences | 8 | 10% |
| Biochemistry, Genetics and Molecular Biology | 7 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 6% |
| Other | 15 | 19% |
| Unknown | 23 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2021.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Cellular and Molecular Neurobiology
#376
of 1,096 outputs
Outputs of similar age
#25,719
of 111,365 outputs
Outputs of similar age from Cellular and Molecular Neurobiology
#2
of 3 outputs
Altmetric has tracked 25,373,627 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,096 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
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