| Title |
Microbiome–host systems interactions: protective effects of propionate upon the blood–brain barrier
|
|---|---|
| Published in |
Microbiome, March 2018
|
| DOI | 10.1186/s40168-018-0439-y |
| Pubmed ID | |
| Authors |
Lesley Hoyles, Tom Snelling, Umm-Kulthum Umlai, Jeremy K. Nicholson, Simon R. Carding, Robert C. Glen, Simon McArthur |
| Abstract |
Gut microbiota composition and function are symbiotically linked with host health and altered in metabolic, inflammatory and neurodegenerative disorders. Three recognised mechanisms exist by which the microbiome influences the gut-brain axis: modification of autonomic/sensorimotor connections, immune activation, and neuroendocrine pathway regulation. We hypothesised interactions between circulating gut-derived microbial metabolites, and the blood-brain barrier (BBB) also contribute to the gut-brain axis. Propionate, produced from dietary substrates by colonic bacteria, stimulates intestinal gluconeogenesis and is associated with reduced stress behaviours, but its potential endocrine role has not been addressed. After demonstrating expression of the propionate receptor FFAR3 on human brain endothelium, we examined the impact of a physiologically relevant propionate concentration (1 μM) on BBB properties in vitro. Propionate inhibited pathways associated with non-specific microbial infections via a CD14-dependent mechanism, suppressed expression of LRP-1 and protected the BBB from oxidative stress via NRF2 (NFE2L2) signalling. Together, these results suggest gut-derived microbial metabolites interact with the BBB, representing a fourth facet of the gut-brain axis that warrants further attention. |
X Demographics
The data shown below were collected from the profiles of 101 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 15 | 15% |
| United Kingdom | 15 | 15% |
| Spain | 7 | 7% |
| India | 7 | 7% |
| France | 2 | 2% |
| Sweden | 2 | 2% |
| Australia | 2 | 2% |
| Germany | 2 | 2% |
| Netherlands | 2 | 2% |
| Other | 12 | 12% |
| Unknown | 35 | 35% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 59 | 58% |
| Scientists | 30 | 30% |
| Practitioners (doctors, other healthcare professionals) | 12 | 12% |
Mendeley readers
The data shown below were compiled from readership statistics for 394 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 394 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 54 | 14% |
| Student > Ph. D. Student | 50 | 13% |
| Student > Master | 39 | 10% |
| Student > Bachelor | 39 | 10% |
| Other | 21 | 5% |
| Other | 59 | 15% |
| Unknown | 132 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 56 | 14% |
| Agricultural and Biological Sciences | 41 | 10% |
| Neuroscience | 38 | 10% |
| Medicine and Dentistry | 30 | 8% |
| Immunology and Microbiology | 26 | 7% |
| Other | 49 | 12% |
| Unknown | 154 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 63. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 December 2023.
All research outputs
#690,320
of 25,736,439 outputs
Outputs from Microbiome
#186
of 1,792 outputs
Outputs of similar age
#15,600
of 348,586 outputs
Outputs of similar age from Microbiome
#10
of 58 outputs
Altmetric has tracked 25,736,439 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,792 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 37.9. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.