| Title |
The listeriolysin O gene: A chromosomal locus crucial for the virulence of Listeria monocytogenes
|
|---|---|
| Published in |
Infection, March 1988
|
| DOI | 10.1007/bf01639740 |
| Pubmed ID | |
| Authors |
P. Cossart |
| Abstract |
In culture supernatants of a Tn 1545-induced non-hemolytic mutant of Listeria monocytogenes, by immunoblotting with an anti-serum raised against purified listeriolysin O, we have detected the presence of a truncated protein of 52,000D (the secreted listeriolysin O is 60,000D). The region of insertion of the transposon has been cloned and sequenced. The transposon had inserted in an open reading frame. The homologies detected between this ORF, streptolysin O and pneumolysin demonstrate the the transposon had indeed inserted in the listeriolysin O gene. As the non-hemolytic mutant was non-virulent, our work demonstrated that a genetic determinant essential for virulence is the listeriolysin O gene or its adjacent region. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 28 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 14% |
| Student > Ph. D. Student | 4 | 14% |
| Researcher | 4 | 14% |
| Student > Master | 4 | 14% |
| Student > Postgraduate | 4 | 14% |
| Other | 3 | 11% |
| Unknown | 5 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 32% |
| Biochemistry, Genetics and Molecular Biology | 3 | 11% |
| Immunology and Microbiology | 3 | 11% |
| Veterinary Science and Veterinary Medicine | 2 | 7% |
| Engineering | 2 | 7% |
| Other | 3 | 11% |
| Unknown | 6 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 April 2022.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Infection
#409
of 1,401 outputs
Outputs of similar age
#3,650
of 12,968 outputs
Outputs of similar age from Infection
#1
of 3 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,401 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.4. This one is in the 42nd percentile – i.e., 42% of its peers scored the same or lower than it.
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