| Title |
Expression of the CCAAT/Enhancer-Binding Proteins C/EBPα, C/EBPβ and C/EBPδ in Breast Cancer: Correlations with Clinicopathologic Parameters and Cell-Cycle Regulatory Proteins
|
|---|---|
| Published in |
Breast Cancer Research and Treatment, May 2003
|
| DOI | 10.1023/a:1023929504884 |
| Pubmed ID | |
| Authors |
Karin Milde-Langosch, Thomas Löning, Ana-Maria Bamberger |
| Abstract |
Members of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors are involved in the regulation of proliferation and differentiation of the mammary gland. In order to investigate the role of C/EBPalpha, -beta and -delta in breast cancer, we performed western blot analysis and partly immunohistochemistry in 75 mammary carcinomas, 10 normal mammary tissue samples and four mammary cell lines. Expression levels of both C/EBPalpha isoforms, C/EBPbeta isoforms LAP1, LAP2 (liver-enriched transcriptional activating proteins), and LIP (liver-enriched transcriptional inhibitory protein), and C/EBPdelta in the tumors were correlated with clinicopathological tumor parameters, expression of estrogen and progesterone receptors (ER, PR), Ki67 immunostaining, and expression of seven cell-cycle regulatory proteins which had been analyzed before. High C/EBPalpha and -delta protein levels correlated significantly with expression of cell-cycle promoters (cyclin D1 and E) and cell-cycle inhibitory proteins (Rb, p27, p16), but with none of the established prognostic parameters. In contrast, statistically significant relationships of the full-length C/EBPbeta isoform LAP1 and a negative estrogen receptor status, high grading, nodal involvement, and high cyclin E and p16 expression were found. For the shorter isoform LIP, correlations with an ER-negative phenotype and high Ki67 immunostaining were detected, and high histological grading (G3) correlated with lower LAP/LIP ratio. These results suggest that high C/EBPbeta expression might be involved in tumor progression and indicative of an unfavorable prognosis. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 25% |
| Student > Ph. D. Student | 8 | 22% |
| Professor > Associate Professor | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Student > Master | 4 | 11% |
| Other | 3 | 8% |
| Unknown | 4 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 31% |
| Medicine and Dentistry | 10 | 28% |
| Biochemistry, Genetics and Molecular Biology | 5 | 14% |
| Computer Science | 1 | 3% |
| Neuroscience | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 7 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 October 2022.
All research outputs
#7,542,164
of 23,009,818 outputs
Outputs from Breast Cancer Research and Treatment
#1,678
of 4,681 outputs
Outputs of similar age
#17,019
of 50,919 outputs
Outputs of similar age from Breast Cancer Research and Treatment
#7
of 21 outputs
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