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X Demographics
Mendeley readers
Attention Score in Context
| Title |
IRF8 Regulates Transcription of Naips for NLRC4 Inflammasome Activation
|
|---|---|
| Published in |
Cell, March 2018
|
| DOI | 10.1016/j.cell.2018.02.055 |
| Pubmed ID | |
| Authors |
Rajendra Karki, Ein Lee, David Place, Parimal Samir, Jayadev Mavuluri, Bhesh Raj Sharma, Arjun Balakrishnan, R K Subbarao Malireddi, Rechel Geiger, Qifan Zhu, Geoffrey Neale, Thirumala-Devi Kanneganti |
| Abstract |
Inflammasome activation is critical for host defenses against various microbial infections. Activation of the NLRC4 inflammasome requires detection of flagellin or type III secretion system (T3SS) components by NLR family apoptosis inhibitory proteins (NAIPs); yet how this pathway is regulated is unknown. Here, we found that interferon regulatory factor 8 (IRF8) is required for optimal activation of the NLRC4 inflammasome in bone-marrow-derived macrophages infected with Salmonella Typhimurium, Burkholderia thailandensis, or Pseudomonas aeruginosa but is dispensable for activation of the canonical and non-canonical NLRP3, AIM2, and Pyrin inflammasomes. IRF8 governs the transcription of Naips to allow detection of flagellin or T3SS proteins to mediate NLRC4 inflammasome activation. Furthermore, we found that IRF8 confers protection against bacterial infection in vivo, owing to its role in inflammasome-dependent cytokine production and pyroptosis. Altogether, our findings suggest that IRF8 is a critical regulator of NAIPs and NLRC4 inflammasome activation for defense against bacterial infection. |
X Demographics
The data shown below were collected from the profiles of 20 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | 20% |
| Belgium | 2 | 10% |
| United Kingdom | 1 | 5% |
| Iraq | 1 | 5% |
| Russia | 1 | 5% |
| Unknown | 11 | 55% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 50% |
| Scientists | 8 | 40% |
| Practitioners (doctors, other healthcare professionals) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 126 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 126 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 31 | 25% |
| Researcher | 15 | 12% |
| Student > Bachelor | 11 | 9% |
| Student > Master | 10 | 8% |
| Other | 7 | 6% |
| Other | 21 | 17% |
| Unknown | 31 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 37 | 29% |
| Biochemistry, Genetics and Molecular Biology | 17 | 13% |
| Agricultural and Biological Sciences | 16 | 13% |
| Medicine and Dentistry | 14 | 11% |
| Nursing and Health Professions | 3 | 2% |
| Other | 4 | 3% |
| Unknown | 35 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 October 2018.
All research outputs
#3,114,827
of 25,382,440 outputs
Outputs from Cell
#7,245
of 17,170 outputs
Outputs of similar age
#62,788
of 347,572 outputs
Outputs of similar age from Cell
#141
of 157 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,170 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,572 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 157 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.