| Title |
Characterization of cDNA clones containing CCA trinucleotide repeats derived from human brain
|
|---|---|
| Published in |
Somatic Cell and Molecular Genetics, July 1995
|
| DOI | 10.1007/bf02255782 |
| Pubmed ID | |
| Authors |
Russell L. Margolis, Theresa S. Breschel, Shi-Hua Li, Arif S. Kidwai, Stylianos E. Antonarakis, Melvin G. McInnis, Christopher A. Ross |
| Abstract |
Expansion mutation is the cause of eight neuropsychiatric disorders. Thus far each disease is the result of expansion of a C-G rich trinucleotide repeat that is polymorphic for length in the general population. We now report the identification of seven novel cDNA clones with CCA or equivalent trinucleotide repeats obtained by screening a human frontal cortex cDNA library. The repeat lengths of two clones, CCA11 (linked to D20S101, expressed in human brain as a 3.2 kb message) and CCA38 (linked to D5S404), are highly polymorphic in a normal human population. CCA54, mapped to chromosome 19, appears to correspond to a portion of the human gene encoding the alpha 1 subunit of a P-type calcium channel. Expansion mutations at these loci should be considered as possible candidates in evaluating the genetic etiologies of diseases linked to chromosomes 5, 19, and 20. |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 25% |
| Student > Bachelor | 1 | 13% |
| Professor > Associate Professor | 1 | 13% |
| Unknown | 4 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 13% |
| Business, Management and Accounting | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Medicine and Dentistry | 1 | 13% |
| Neuroscience | 1 | 13% |
| Other | 0 | 0% |
| Unknown | 3 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2007.
All research outputs
#4,696,396
of 22,788,370 outputs
Outputs from Somatic Cell and Molecular Genetics
#14
of 262 outputs
Outputs of similar age
#3,067
of 24,066 outputs
Outputs of similar age from Somatic Cell and Molecular Genetics
#1
of 4 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 262 research outputs from this source. They receive a mean Attention Score of 3.8. This one has done well, scoring higher than 77% of its peers.
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