| Title |
Three-dimensional organization and dynamics of the genome
|
|---|---|
| Published in |
Cell Biology and Toxicology, March 2018
|
| DOI | 10.1007/s10565-018-9428-y |
| Pubmed ID | |
| Authors |
Przemyslaw Szalaj, Dariusz Plewczynski |
| Abstract |
Genome is a complex hierarchical structure, and its spatial organization plays an important role in its function. Chromatin loops and topological domains form the basic structural units of this multiscale organization and are essential to orchestrate complex regulatory networks and transcription mechanisms. They also form higher-order structures such as chromosomal compartments and chromosome territories. Each level of this intrinsic architecture is governed by principles and mechanisms that we only start to understand. In this review, we summarize the current view of the genome architecture on the scales ranging from chromatin loops to the whole genome. We describe cell-to-cell variability, links between genome reorganization and various genomic processes, such as chromosome X inactivation and cell differentiation, and the interplay between different experimental techniques. |
X Demographics
The data shown below were collected from the profiles of 7 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| France | 2 | 29% |
| United Kingdom | 1 | 14% |
| Malaysia | 1 | 14% |
| Unknown | 3 | 43% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 128 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 128 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 35 | 27% |
| Researcher | 17 | 13% |
| Student > Master | 10 | 8% |
| Student > Bachelor | 8 | 6% |
| Student > Doctoral Student | 6 | 5% |
| Other | 20 | 16% |
| Unknown | 32 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 48 | 38% |
| Agricultural and Biological Sciences | 23 | 18% |
| Medicine and Dentistry | 4 | 3% |
| Computer Science | 4 | 3% |
| Physics and Astronomy | 4 | 3% |
| Other | 7 | 5% |
| Unknown | 38 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2021.
All research outputs
#4,507,261
of 24,140,950 outputs
Outputs from Cell Biology and Toxicology
#48
of 503 outputs
Outputs of similar age
#85,421
of 336,339 outputs
Outputs of similar age from Cell Biology and Toxicology
#3
of 7 outputs
Altmetric has tracked 24,140,950 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 503 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 336,339 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.