| Title |
Organ-specific metastasis of breast cancer: molecular and cellular mechanisms underlying lung metastasis
|
|---|---|
| Published in |
Cellular Oncology, March 2018
|
| DOI | 10.1007/s13402-018-0376-6 |
| Pubmed ID | |
| Authors |
Meysam Yousefi, Rahim Nosrati, Arash Salmaninejad, Sadegh Dehghani, Alireza Shahryari, Alihossein Saberi |
| Abstract |
Breast cancer (BC) is the most common type of cancer in women and the second cause of cancer-related mortality world-wide. The majority of BC-related deaths is due to metastasis. Bone, lung, brain and liver are the primary target sites of BC metastasis. The clinical implications and mechanisms underlying bone metastasis have been reviewed before. Given the fact that BC lung metastasis (BCLM) usually produces symptoms only after the lungs have been vastly occupied with metastatic tumor masses, it is of paramount importance for diagnostic and prognostic, as well as therapeutic purposes to comprehend the molecular and cellular mechanisms underlying BCLM. Here, we review current insights into the organ-specificity of BC metastasis, including the role of cancer stem cells in triggering BC spread, the traveling of tumor cells in the blood stream and their migration across endothelial barriers, their adaptation to the lung microenvironment and the initiation of metastatic colonization within the lung. Detailed understanding of the mechanisms underlying BCLM will shed a new light on the identification of novel molecular targets to impede daunting pulmonary metastases in patients with breast cancer. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 132 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 18 | 14% |
| Student > Bachelor | 17 | 13% |
| Student > Master | 15 | 11% |
| Student > Doctoral Student | 10 | 8% |
| Researcher | 8 | 6% |
| Other | 17 | 13% |
| Unknown | 47 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 26 | 20% |
| Medicine and Dentistry | 18 | 14% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 11% |
| Agricultural and Biological Sciences | 7 | 5% |
| Immunology and Microbiology | 4 | 3% |
| Other | 9 | 7% |
| Unknown | 54 | 41% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 March 2018.
All research outputs
#19,516,978
of 23,999,200 outputs
Outputs from Cellular Oncology
#259
of 426 outputs
Outputs of similar age
#263,210
of 336,038 outputs
Outputs of similar age from Cellular Oncology
#5
of 8 outputs
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