| Title |
Feasibility of fluorescence lymph node imaging in colon cancer: FLICC
|
|---|---|
| Published in |
Techniques in Coloproctology, March 2018
|
| DOI | 10.1007/s10151-018-1773-6 |
| Pubmed ID | |
| Authors |
M. Chand, D. S. Keller, H. M. Joshi, L. Devoto, M. Rodriguez-Justo, R. Cohen |
| Abstract |
In colon cancer, appropriate tumour excision and associated lymphadenectomy directly impact recurrence and survival outcomes. Currently, there is no standard for mesenteric lymphadenectomy, with a lymph node yield of 12 acting as a surrogate quality marker. Our goal was to determine the safety and feasibility of indocyanine green (ICG) fluorescence imaging to demonstrate lymphatic drainage in colon cancer in a dose-escalation study. A prospective pilot study of colon cancer patients undergoing curative laparoscopic resection was performed. At surgery, peritumoural subserosal ICG injection was done to demonstrate lymphatic drainage of the tumour. A specialized fluorescence system excited the ICG and assessed lymphatics in real time. The primary outcome was the feasibility of ICG fluorescent lymphangiography for lymphatic drainage in colon cancer. Secondary outcomes were the optimal protocol for dose, injection site, and ICG lymphatic mapping timing. Ten consecutive patients were evaluated (six males, mean age 69.5 years). In all, lymphatic channels were seen around the tumour to a varying extent. Eight (80%) had drainage to the sentinel node. In all cases where the lymphatic map was seen, there was no further spread 10 min after injection. In 2 patients (20%), additional lymph nodes located outside of the proposed resection margins were demonstrated. In both cases the resection was extended to include the nodes and in both patients these nodes were positive on histopathology. Factors contributing to reduced lymphatic visualization were inadequate ICG concentrations, excess India ink blocking drainage, and inflammation from tattoo placement. ICG can be safely injected into the peritumoural subserosal and demonstrate lymphatic drainage in colon cancer. This proof of concept and proposed standards for the procedure can lead to future studies to optimize the application of image-guided precision surgery in colon cancer. Furthermore, this technique may be of value in indicating the need for more extended lymphadenectomy. |
X Demographics
The data shown below were collected from the profiles of 63 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 16% |
| Spain | 8 | 13% |
| United Kingdom | 7 | 11% |
| Italy | 3 | 5% |
| Poland | 2 | 3% |
| United Arab Emirates | 1 | 2% |
| France | 1 | 2% |
| Brazil | 1 | 2% |
| Egypt | 1 | 2% |
| Other | 6 | 10% |
| Unknown | 23 | 37% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 43% |
| Practitioners (doctors, other healthcare professionals) | 23 | 37% |
| Scientists | 10 | 16% |
| Science communicators (journalists, bloggers, editors) | 3 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 16% |
| Student > Ph. D. Student | 9 | 13% |
| Researcher | 8 | 11% |
| Student > Doctoral Student | 6 | 9% |
| Student > Bachelor | 6 | 9% |
| Other | 11 | 16% |
| Unknown | 19 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 45 | 64% |
| Engineering | 2 | 3% |
| Immunology and Microbiology | 1 | 1% |
| Biochemistry, Genetics and Molecular Biology | 1 | 1% |
| Neuroscience | 1 | 1% |
| Other | 1 | 1% |
| Unknown | 19 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 34. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 December 2020.
All research outputs
#1,160,533
of 25,271,884 outputs
Outputs from Techniques in Coloproctology
#55
of 1,356 outputs
Outputs of similar age
#27,469
of 366,183 outputs
Outputs of similar age from Techniques in Coloproctology
#2
of 23 outputs
Altmetric has tracked 25,271,884 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,356 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has done particularly well, scoring higher than 96% of its peers.
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We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.