| Title |
Association of Depressive Symptoms with Lapses in Antiretroviral Medication Adherence Among People Living with HIV: A Test of an Indirect Pathway
|
|---|---|
| Published in |
AIDS and Behavior, March 2018
|
| DOI | 10.1007/s10461-018-2098-1 |
| Pubmed ID | |
| Authors |
Jacklyn D. Babowitch, Alan Z. Sheinfil, Sarah E. Woolf-King, Peter A. Vanable, Shannon M. Sweeney |
| Abstract |
Viral suppression, a critical component of HIV care, is more likely when individuals initiate antiretroviral therapy (ART) early in disease progression and maintain optimal levels of adherence to ART regimens. Although several studies have documented the negative association of depressive symptoms with ART adherence, less is known about how depressed mood relates to intentional versus unintentional lapses in adherence as well as the mechanisms underlying this association. The purpose of the current study was to examine the association of depressive symptoms with ART adherence, assessed as a multidimensional construct. Secondarily, this study conducted preliminary indirect path models to determine if medication self-efficacy could explain the depressed mood-adherence relationship. Depressive symptoms were not associated with 95% ART taken, self-reported viral load, deliberate adjustments to ART regimens or skipped ART doses. However, the indirect association of depressive symptoms via decrements in medication self-efficacy was significant for 95% ART taken, self-reported viral load and skipped ART doses, but not deliberate changes to ART regimens. In this sample of HIV-positive outpatients, there is evidence to support medication self-efficacy as a potential mechanism underlying the association between depressive symptoms and ART adherence. Additional longitudinal studies are needed to formally examine medication taking self-efficacy as a mediator. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Italy | 1 | 50% |
| United States | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 51 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 51 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 14% |
| Student > Bachelor | 7 | 14% |
| Student > Master | 6 | 12% |
| Professor > Associate Professor | 4 | 8% |
| Researcher | 3 | 6% |
| Other | 10 | 20% |
| Unknown | 14 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 8 | 16% |
| Nursing and Health Professions | 7 | 14% |
| Medicine and Dentistry | 6 | 12% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 6% |
| Social Sciences | 3 | 6% |
| Other | 6 | 12% |
| Unknown | 18 | 35% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 April 2018.
All research outputs
#16,496,276
of 24,344,498 outputs
Outputs from AIDS and Behavior
#2,555
of 3,617 outputs
Outputs of similar age
#215,040
of 335,068 outputs
Outputs of similar age from AIDS and Behavior
#60
of 90 outputs
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