| Title |
ST2: A Novel Remodeling Biomarker in Acute and Chronic Heart Failure
|
|---|---|
| Published in |
Current Heart Failure Reports, February 2010
|
| DOI | 10.1007/s11897-010-0005-9 |
| Pubmed ID | |
| Authors |
Ravi V. Shah, James L. Januzzi |
| Abstract |
ST2, a member of the interleukin-1 receptor family, is a novel biomarker of mechanical stress measurable in serum that has been shown in animal and in vitro models to be physiologically linked to cardiac hypertrophy, fibrosis, and ventricular dysfunction. In patients with acute myocardial infarction and heart failure (HF), an elevated serum level of the soluble isoform of ST2 is associated with an increased risk of mortality or future HF, independent of natriuretic peptides, and correlates with markers of ventricular structure and function. In acute HF, elevated soluble ST2 levels strongly associate with the presence and severity of the disease and forecast short- and long-term mortality independent of other traditional clinical, biochemical, and echocardiographic markers of risk. This review discusses the biology and physiology of ST2, as well as its implications on the pathogenesis and prognosis of patients with acute coronary syndromes or acute and chronic HF syndromes. |
Mendeley readers
The data shown below were compiled from readership statistics for 73 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Germany | 1 | 1% |
| Unknown | 71 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 16% |
| Student > Doctoral Student | 10 | 14% |
| Student > Master | 9 | 12% |
| Researcher | 8 | 11% |
| Professor | 6 | 8% |
| Other | 15 | 21% |
| Unknown | 13 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 36 | 49% |
| Agricultural and Biological Sciences | 9 | 12% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Chemistry | 3 | 4% |
| Engineering | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 13 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 July 2021.
All research outputs
#3,272,274
of 22,788,370 outputs
Outputs from Current Heart Failure Reports
#46
of 315 outputs
Outputs of similar age
#13,084
of 93,895 outputs
Outputs of similar age from Current Heart Failure Reports
#1
of 4 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 315 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.6. This one has done well, scoring higher than 85% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 93,895 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 4 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them