| Title |
Refined mapping and characterization of the recessive familial amyotrophic lateral sclerosis locus (ALS2) on chromosome 2q33
|
|---|---|
| Published in |
neurogenetics, December 1998
|
| DOI | 10.1007/s100480050049 |
| Pubmed ID | |
| Authors |
Betsy A. Hosler, Peter C. Sapp, Ralph Berger, Gilmore O'Neill, Khemissa Bejaoui, Mongi Ben Hamida, Faycal Hentati, Wendy Chin, Diane McKenna-Yasek, Jonathan L. Haines, David Patterson, H. Robert Horvitz, R. H. Brown Jr., C. B. Day |
| Abstract |
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative neuromuscular disease that shows familial, autosomal dominant inheritance in 10%-15% of cases. Previous genetic analysis of one large family linked a recessive form of familial ALS (FALS-AR type 3) to the chromosome 2q33-35 region. Using additional polymorphic markers, we have narrowed the size of the linked region to approximately 1.7 cM by linkage and haplotype analysis. We have also established a yeast artificial chromosome contig across the locus that covers an approximate physical distance of 3 million bases. Based on this contig, genes and expressed sequences that map near the 2q33 region have been examined to determine whether they are located within this ALS2 candidate locus. Five identified genes and 34 expressed sequence tags map within the region defined by crossover analysis and merit further consideration as candidate genes for this disease. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 3% |
| Australia | 1 | 3% |
| Unknown | 30 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 22% |
| Researcher | 6 | 19% |
| Student > Bachelor | 4 | 13% |
| Professor > Associate Professor | 3 | 9% |
| Lecturer > Senior Lecturer | 2 | 6% |
| Other | 6 | 19% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 28% |
| Medicine and Dentistry | 7 | 22% |
| Biochemistry, Genetics and Molecular Biology | 3 | 9% |
| Nursing and Health Professions | 2 | 6% |
| Computer Science | 2 | 6% |
| Other | 2 | 6% |
| Unknown | 7 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from neurogenetics
#116
of 376 outputs
Outputs of similar age
#21,738
of 99,619 outputs
Outputs of similar age from neurogenetics
#3
of 4 outputs
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