Title |
A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma
|
---|---|
Published in |
Science, December 1991
|
DOI | 10.1126/science.1840703 |
Pubmed ID | |
Authors |
P. van der Bruggen, C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, B. Van den Eynde, A. Knuth, T. Boon |
Abstract |
Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the gene. Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 4 | <1% |
Brazil | 3 | <1% |
United Kingdom | 2 | <1% |
France | 1 | <1% |
Malaysia | 1 | <1% |
Singapore | 1 | <1% |
Germany | 1 | <1% |
Russia | 1 | <1% |
Luxembourg | 1 | <1% |
Other | 0 | 0% |
Unknown | 892 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 228 | 25% |
Student > Master | 119 | 13% |
Researcher | 113 | 12% |
Student > Bachelor | 104 | 11% |
Student > Doctoral Student | 64 | 7% |
Other | 121 | 13% |
Unknown | 158 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 233 | 26% |
Medicine and Dentistry | 151 | 17% |
Biochemistry, Genetics and Molecular Biology | 147 | 16% |
Immunology and Microbiology | 133 | 15% |
Pharmacology, Toxicology and Pharmaceutical Science | 18 | 2% |
Other | 51 | 6% |
Unknown | 174 | 19% |