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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A Gene Encoding an Antigen Recognized by Cytolytic T Lymphocytes on a Human Melanoma
|
|---|---|
| Published in |
Science, December 1991
|
| DOI | 10.1126/science.1840703 |
| Pubmed ID | |
| Authors |
P. van der Bruggen, C. Traversari, P. Chomez, C. Lurquin, E. De Plaen, B. Van den Eynde, A. Knuth, T. Boon |
| Abstract |
Many human melanoma tumors express antigens that are recognized in vitro by cytolytic T lymphocytes (CTLs) derived from the tumor-bearing patient. A gene was identified that directed the expression of antigen MZ2-E on a human melanoma cell line. This gene shows no similarity to known sequences and belongs to a family of at least three genes. It is expressed by the original melanoma cells, other melanoma cell lines, and by some tumor cells of other histological types. No expression was observed in a panel of normal tissues. Antigen MZ2-E appears to be presented by HLA-A1; anti-MZ2-E CTLs of the original patient recognized two melanoma cell lines of other HLA-A1 patients that expressed the gene. Thus, precisely targeted immunotherapy directed against antigen MZ2-E could be provided to individuals identified by HLA typing and analysis of the RNA of a small tumor sample. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 907 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 4 | <1% |
| Brazil | 3 | <1% |
| United Kingdom | 2 | <1% |
| France | 1 | <1% |
| Malaysia | 1 | <1% |
| Singapore | 1 | <1% |
| Germany | 1 | <1% |
| Russia | 1 | <1% |
| Luxembourg | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 892 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 228 | 25% |
| Student > Master | 119 | 13% |
| Researcher | 113 | 12% |
| Student > Bachelor | 104 | 11% |
| Student > Doctoral Student | 64 | 7% |
| Other | 121 | 13% |
| Unknown | 158 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 233 | 26% |
| Medicine and Dentistry | 151 | 17% |
| Biochemistry, Genetics and Molecular Biology | 147 | 16% |
| Immunology and Microbiology | 133 | 15% |
| Pharmacology, Toxicology and Pharmaceutical Science | 18 | 2% |
| Other | 51 | 6% |
| Unknown | 174 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 53. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 April 2024.
All research outputs
#815,792
of 26,017,215 outputs
Outputs from Science
#16,583
of 83,593 outputs
Outputs of similar age
#297
of 62,544 outputs
Outputs of similar age from Science
#8
of 188 outputs
Altmetric has tracked 26,017,215 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,593 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 62,544 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 188 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.