Title |
A new gene coding for an antigen recognized by autologous cytolytic T lymphocytes on a human renal carcinoma
|
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Published in |
Immunogenetics, September 1996
|
DOI | 10.1007/bf02602776 |
Pubmed ID | |
Authors |
Béatrice Gaugler, Nathalie Brouwenstijn, Valérie Vantomme, Jean-Pierre Szikora, Corry W. Van der Spek, Jean-Jacques Patard, Thierry Boon, Peter Schrier, Benoît J. Van den Eynde |
Abstract |
Previous reports have described antigens that are recognized on human melanoma cells by autologous cytolytic T lymphocytes (CTL). The genes coding for a number of these antigens have been identified. Here we report the cloning of a gene that codes for an antigen recognized by autologous CTL on a human renal carcinoma cell line. This antigen is presented by HLA-B7 and is encoded by a new gene that we have named RAGE1. No expression of RAGE1 was found in normal tissues other than retina. RAGE1 expression was found in only one of 57 renal cell carcinoma samples, and also in some sarcomas, infiltrating bladder carcinomas, and melanomas. This represents the first identification of an antigen recognized by autologous CTL on a renal tumor. |
Mendeley readers
Geographical breakdown
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Demographic breakdown
Readers by professional status | Count | As % |
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Other | 3 | 9% |
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