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Mendeley readers
Attention Score in Context
| Title |
Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries
|
|---|---|
| Published in |
International Journal of Cancer, May 2003
|
| DOI | 10.1002/ijc.11208 |
| Pubmed ID | |
| Authors |
Uta Behrends, Inken Schneider, Sabine Rössler, Heinrich Frauenknecht, Anja Golbeck, Brigitte Lechner, Gerhard Eigenstetter, Colette Zobywalski, Stephan Müller‐Weihrich, Ulrike Graubner, Irene Schmid, Dieter Sackerer, Manfred Späth, Claudia Goetz, Franz Prantl, Hans‐Peter Asmuss, Karl Bise, Josef Mautner |
| Abstract |
Medulloblastoma is an embryonal childhood malignancy with poor prognosis. By screening 4 medulloblastoma cDNA expression libraries (SEREX) with autologous sera, 15 different antigens were identified. These antigens were encoded by 3 novel genes, genes of unknown function (KIAA0445, KIAA1853, KIAA0665, FLJ13942, HSPC213), a proto-oncogene (rab18), candidate tumor suppressor genes (BAP1, PRDM13) and genes encoding a motor protein (kinesin-2), a histone (H2A1.2), the ankyrin residue-rich nasopharyngeal cancer susceptibility protein (NZ16) and the transcription factor TZP, which is homologous to the tumor-associated antigens HCA58 and GLEA2. In a consecutive analysis of serum antibody titers and tumor load, a more than 10-fold increase in serum antibodies against PRDM13 preceded the clinical diagnosis of recurrent tumor growth in a patient with aggressive large cell medulloblastoma. When sera of pediatric patients with cancer (n = 40) and healthy controls (n = 40) were tested for humoral responses against the SEREX-defined antigens, 5 antigens were exclusively recognized by sera from cancer patients. These antigens included a novel rab18 gene product translated from mRNA sequences formerly described as 3' untranslated region. Humoral responses against 2 of the remaining 10 antigens were found preferentially in cancer patients. Antibodies against these antigens were detected in 8/40 and 12/40 cancer patients, respectively, but in only 1 healthy control. The 2 antigens were characterized by a tumor-specific deletion and a tumor-specific mutation, respectively. These findings indicate that the humoral immune response against medulloblastoma is directed against diverse antigens that may be useful as diagnostic markers or targets for immunotherapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 32 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 31 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 11 | 34% |
| Student > Bachelor | 6 | 19% |
| Student > Ph. D. Student | 6 | 19% |
| Student > Postgraduate | 2 | 6% |
| Lecturer > Senior Lecturer | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 4 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 16 | 50% |
| Biochemistry, Genetics and Molecular Biology | 7 | 22% |
| Neuroscience | 2 | 6% |
| Psychology | 1 | 3% |
| Immunology and Microbiology | 1 | 3% |
| Other | 0 | 0% |
| Unknown | 5 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 May 2021.
All research outputs
#3,642,454
of 24,627,841 outputs
Outputs from International Journal of Cancer
#1,593
of 12,093 outputs
Outputs of similar age
#5,211
of 52,464 outputs
Outputs of similar age from International Journal of Cancer
#10
of 89 outputs
Altmetric has tracked 24,627,841 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 12,093 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 52,464 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 89 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 85% of its contemporaries.