| Title |
Characteristics of patients with depression initiating or switching antidepressant treatment: baseline analyses of the PERFORM cohort study
|
|---|---|
| Published in |
BMC Psychiatry, March 2018
|
| DOI | 10.1186/s12888-018-1657-3 |
| Pubmed ID | |
| Authors |
Josep Maria Haro, François-Xavier Lamy, Bengt Jönsson, Martin Knapp, Mélanie Brignone, Hugo Caillou, Ylana Chalem, Lene Hammer-Helmich, Benoît Rive, Delphine Saragoussi |
| Abstract |
Patients who require a switch in their antidepressant therapy may have different clinical profiles and treatment needs compared with patients initiating or maintaining a first-line antidepressant therapy. The Prospective Epidemiological Research on Functioning Outcomes Related to Major depressive disorder (MDD) (PERFORM) study was a 2-year observational cohort study in outpatients with MDD in five European countries. Enrolled patients were either initiating or undergoing the first switch to an antidepressant monotherapy. Baseline data on patients' clinical status, functioning, productivity, quality of life and medical-resource use were compared in a cross-sectional baseline analysis. A total of 1402 patients were enrolled, of whom 1159 (82.7%) provided analysable baseline data. The majority (78.7%) of the analysable population were initiating antidepressant treatment and most (83.6%) were enrolled and followed up by general practitioners. Compared with patients initiating antidepressants, those switching antidepressants (21.3%) tended to have more severe depressive symptoms, greater anxiety, worse health-related quality of life, greater functional impairment, greater medical-resource use and had a different medical history. Limitations included an over-representation of switches due to lack of efficacy among patients who were switching treatment, as patients were selected based on presence of depressive symptoms. Patients with MDD who are switching treatment for the first time have a different profile and different depression-associated health needs compared with those initiating treatment. Therapeutic management should therefore be adapted for patients who switch. ClinicalTrials.gov NCT01427439 ; Retrospectively registered 26 August 2011. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Canada | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 65 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 65 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 11 | 17% |
| Student > Master | 9 | 14% |
| Other | 4 | 6% |
| Student > Ph. D. Student | 4 | 6% |
| Student > Doctoral Student | 3 | 5% |
| Other | 9 | 14% |
| Unknown | 25 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 10 | 15% |
| Nursing and Health Professions | 9 | 14% |
| Psychology | 4 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 5% |
| Business, Management and Accounting | 3 | 5% |
| Other | 8 | 12% |
| Unknown | 28 | 43% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 July 2018.
All research outputs
#15,964,360
of 25,262,379 outputs
Outputs from BMC Psychiatry
#3,576
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#194,356
of 336,020 outputs
Outputs of similar age from BMC Psychiatry
#72
of 83 outputs
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