| Title |
Genomic organization of the human leukocyte immunoglobulin-like receptors within the leukocyte receptor complex on Chromosome 19q13.4
|
|---|---|
| Published in |
Immunogenetics, July 2000
|
| DOI | 10.1007/s002510000183 |
| Pubmed ID | |
| Authors |
W. Robert Liu, Joomyeong Kim, Chioma Nwankwo, Linda K. Ashworth, J. P. Arm |
| Abstract |
The leukocyte immunoglobulin (Ig)-like receptors (LIRs) comprise a family of cell surface receptors that couple to either activating or inhibitory signals depending on the nature of their transmembrane and cytoplasmic domains. We describe the organization and fine localization of the genes for LIR-1 and LIR-5, which are inhibitory receptors, and LIR-6, which is an activating receptor. The genomic organization of all three genes is highly conserved from the signal peptide through the membrane-proximal Ig domain but diverges thereafter depending on the inhibitory or activating nature of the gene product. The 3' untranslated region of the gene for LIR-6 contains a 37-base pair repeat not present in the LIR-1 or LIR-5 genes. 5' rapid amplification of cDNA ends defined the putative transcription initiation site of the LIR-5 gene, which is TATA-less. A nucleotide substitution in the LIR-5 gene led to loss of an intron present in the 5' untranslated region of the LIR-1 and LIR-6 genes. Differences in the genomic structure of these three LIR genes suggests possible mechanisms for their differential expression in cells of hematopoietic lineage. The three genes are in a region of Chromosome 19q13.4 that is immediately centromeric of the killer cell Ig-like receptor genes and are separated from one another by approximately 20 to 30 kb, suggesting that they arose by gene duplication from a common ancestor. |
Mendeley readers
The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Montenegro | 1 | 5% |
| Unknown | 19 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 25% |
| Researcher | 4 | 20% |
| Student > Bachelor | 3 | 15% |
| Professor | 1 | 5% |
| Student > Master | 1 | 5% |
| Other | 3 | 15% |
| Unknown | 3 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 6 | 30% |
| Agricultural and Biological Sciences | 4 | 20% |
| Biochemistry, Genetics and Molecular Biology | 4 | 20% |
| Medicine and Dentistry | 1 | 5% |
| Chemistry | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 4 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 September 2020.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Immunogenetics
#350
of 1,215 outputs
Outputs of similar age
#13,226
of 39,275 outputs
Outputs of similar age from Immunogenetics
#4
of 12 outputs
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