| Title |
Cloning and chromosomal location of human genes inducible by type I interferon
|
|---|---|
| Published in |
Somatic Cell and Molecular Genetics, September 1988
|
| DOI | 10.1007/bf01534709 |
| Pubmed ID | |
| Authors |
Marc G. Wathelet, Josiane Szpirer, Christine B. Nols, Isabelle M. Clauss, Lukas Wit, M. Quamrul Islam, G�ran Levan, Michel A. Horisberger, Jean Content, Claude Szpirer, Georges A. Huez |
| Abstract |
When cells are treated with interferon several new proteins are induced. We have isolated by differential screening two cDNA clones corresponding to human genes inducible by IFN-alpha, termed IFI-4 and IFI-54K. The accumulation of the corresponding mRNA was followed as a function of either IFN dose or of time. The IFI-4 and IFI-54K genes, as well as two previously isolated IFN-inducible genes, namely the IFI-56K and low-molecular-weight 2-5A synthetase, were localized on the human chromosomes. Using cloned probes on Southern blots of DNA from a panel of rodent-human somatic cell hybrids, we have assigned the IFI-4 gene to chromosome 1 and the gene coding for the low-molecular-weight 2-5A synthetase to chromosome 12. We also showed that the IFI-54K and IFI-56K genes, unlike most of the IFN-inducible genes, are syntenic. They are both located on chromosome 10. In addition, evidence is given for the presence of a pseudogene homologous to IFI-56K on chromosome 13. |
Mendeley readers
The data shown below were compiled from readership statistics for 7 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 7 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 57% |
| Researcher | 2 | 29% |
| Student > Master | 1 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 3 | 43% |
| Immunology and Microbiology | 2 | 29% |
| Computer Science | 1 | 14% |
| Biochemistry, Genetics and Molecular Biology | 1 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 July 2020.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Somatic Cell and Molecular Genetics
#63
of 262 outputs
Outputs of similar age
#3,740
of 13,075 outputs
Outputs of similar age from Somatic Cell and Molecular Genetics
#1
of 2 outputs
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