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Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22

Overview of attention for article published in Genome Research, December 2002
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • Above-average Attention Score compared to outputs of the same age and source (57th percentile)

Mentioned by

patent
2 patents
wikipedia
33 Wikipedia pages

Citations

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72 Dimensions

Readers on

mendeley
42 Mendeley
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Title
Reevaluating Human Gene Annotation: A Second-Generation Analysis of Chromosome 22
Published in
Genome Research, December 2002
DOI 10.1101/gr.695703
Pubmed ID
Authors

John E. Collins, Melanie E. Goward, Charlotte G. Cole, Luc J. Smink, Elizabeth J. Huckle, Sarah Knowles, Jacqueline M. Bye, David M. Beare, Ian Dunham

Abstract

We report a second-generation gene annotation of human chromosome 22. Using expressed sequence databases, comparative sequence analysis, and experimental verification, we have extended genes, fused previously fragmented structures, and identified new genes. The total length in exons of annotation was increased by 74% over our previously published annotation and includes 546 protein-coding genes and 234 pseudogenes. Thirty-two potential protein-coding annotations are partial copies of other genes, and may represent duplications on an evolutionary path to change or loss of function. We also identified 31 non-protein-coding transcripts, including 16 possible antisense RNAs. By extrapolation, we estimate the human genome contains 29,000-36,000 protein-coding genes, 21,300 pseudogenes, and 1500 antisense RNAs. We suggest that our revised annotation criteria provide a paradigm for future annotation of the human genome.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
Spain 1 2%
United States 1 2%
Belgium 1 2%
Unknown 38 90%

Demographic breakdown

Readers by professional status Count As %
Researcher 10 24%
Professor > Associate Professor 8 19%
Professor 6 14%
Student > Bachelor 4 10%
Student > Postgraduate 3 7%
Other 7 17%
Unknown 4 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 20 48%
Biochemistry, Genetics and Molecular Biology 6 14%
Medicine and Dentistry 3 7%
Engineering 2 5%
Business, Management and Accounting 1 2%
Other 6 14%
Unknown 4 10%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 July 2022.
All research outputs
#4,715,512
of 22,867,327 outputs
Outputs from Genome Research
#2,184
of 4,251 outputs
Outputs of similar age
#14,438
of 129,370 outputs
Outputs of similar age from Genome Research
#20
of 56 outputs
Altmetric has tracked 22,867,327 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,251 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 16.7. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 129,370 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 56 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 57% of its contemporaries.