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Mendeley readers
Attention Score in Context
| Title |
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4
|
|---|---|
| Published in |
Nature Genetics, May 2010
|
| DOI | 10.1038/ng.580 |
| Pubmed ID | |
| Authors |
Terri H Beaty, Jeffrey C Murray, Mary L Marazita, Ronald G Munger, Ingo Ruczinski, Jacqueline B Hetmanski, Kung Yee Liang, Tao Wu, Tanda Murray, M Daniele Fallin, Richard A Redett, Gerald Raymond, Holger Schwender, Sheng-Chih Jin, Margaret E Cooper, Martine Dunnwald, Maria A Mansilla, Elizabeth Leslie, Stephen Bullard, Andrew C Lidral, Lina M Moreno, Renato Menezes, Alexandre R Vieira, Aline Petrin, Allen J Wilcox, Rolv T Lie, Ethylin W Jabs, Yah Huei Wu-Chou, Philip K Chen, Hong Wang, Xiaoqian Ye, Shangzhi Huang, Vincent Yeow, Samuel S Chong, Sun Ha Jee, Bing Shi, Kaare Christensen, Mads Melbye, Kimberly F Doheny, Elizabeth W Pugh, Hua Ling, Eduardo E Castilla, Andrew E Czeizel, Lian Ma, L Leigh Field, Lawrence Brody, Faith Pangilinan, James L Mills, Anne M Molloy, Peadar N Kirke, John M Scott, Mauricio Arcos-Burgos, Alan F Scott |
| Abstract |
Case-parent trios were used in a genome-wide association study of cleft lip with and without cleft palate. SNPs near two genes not previously associated with cleft lip with and without cleft palate (MAFB, most significant SNP rs13041247, with odds ratio (OR) per minor allele = 0.704, 95% CI 0.635-0.778, P = 1.44 x 10(-11); and ABCA4, most significant SNP rs560426, with OR = 1.432, 95% CI 1.292-1.587, P = 5.01 x 10(-12)) and two previously identified regions (at chromosome 8q24 and IRF6) attained genome-wide significance. Stratifying trios into European and Asian ancestry groups revealed differences in statistical significance, although estimated effect sizes remained similar. Replication studies from several populations showed confirming evidence, with families of European ancestry giving stronger evidence for markers in 8q24, whereas Asian families showed stronger evidence for association with MAFB and ABCA4. Expression studies support a role for MAFB in palatal development. |
Mendeley readers
The data shown below were compiled from readership statistics for 236 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 3% |
| Brazil | 2 | <1% |
| United Kingdom | 2 | <1% |
| Canada | 1 | <1% |
| Tanzania, United Republic of | 1 | <1% |
| Unknown | 224 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 47 | 20% |
| Student > Ph. D. Student | 38 | 16% |
| Student > Doctoral Student | 22 | 9% |
| Student > Master | 18 | 8% |
| Student > Postgraduate | 16 | 7% |
| Other | 50 | 21% |
| Unknown | 45 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 73 | 31% |
| Agricultural and Biological Sciences | 67 | 28% |
| Biochemistry, Genetics and Molecular Biology | 32 | 14% |
| Mathematics | 3 | 1% |
| Computer Science | 2 | <1% |
| Other | 8 | 3% |
| Unknown | 51 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 March 2018.
All research outputs
#4,696,560
of 22,788,370 outputs
Outputs from Nature Genetics
#4,225
of 7,187 outputs
Outputs of similar age
#20,043
of 95,274 outputs
Outputs of similar age from Nature Genetics
#30
of 45 outputs
Altmetric has tracked 22,788,370 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 41.0. This one is in the 32nd percentile – i.e., 32% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 95,274 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 45 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.