| Title |
The human natural killer gene complex is located on chromosome 12p12-p13
|
|---|---|
| Published in |
Immunogenetics, July 1997
|
| DOI | 10.1007/s002510050276 |
| Pubmed ID | |
| Authors |
Mónica Renedo, Ignacio Arce, Antonio Rodríguez, Marta Carretero, Lewis L. Lanier, Miguel López-Botet, E. Fernández-Ruiz |
| Abstract |
Natural killer (NK) cells preferentially express several type II glycoproteins of the calcium-dependent lectin superfamily. The genes coding for these molecules are clustered on the distal mouse chromosome 6 and on the rat chromosome 4 in a region designated the NK gene complex. To date, no definite evidence of the presence of a NK gene complex has been found in humans. Here we report the assignment by fluorescence in situ hybridization of the CD94 gene to human chromosome 12p12-p13, in the same region where the CD69 and NKG2A genes had been previously mapped. In addition, using a yeast artificial chromosome contig spanning this region we determined that the human CD94, NKG2A, NKG2C, NKG2E, and NKR-P1A (NKR) genes map to the short arm of chromosome 12. The distal to proximal position of these loci are: NKR- CD69 - CD94/NKG2A/NKG2C/NKG2E. These data demonstrate the existence of a human NK gene complex located within a 5.6 cM interval flanked by the genetic markers D12S397 and D12S89. The physical distance spanned by the NK gene complex in humans ranges between 0.7 and 2.4 megabases. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Singapore | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 7 | 27% |
| Professor | 4 | 15% |
| Researcher | 3 | 12% |
| Student > Bachelor | 3 | 12% |
| Professor > Associate Professor | 3 | 12% |
| Other | 3 | 12% |
| Unknown | 3 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 11 | 42% |
| Immunology and Microbiology | 4 | 15% |
| Medicine and Dentistry | 4 | 15% |
| Biochemistry, Genetics and Molecular Biology | 2 | 8% |
| Chemistry | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 4 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 November 2020.
All research outputs
#8,534,528
of 25,373,627 outputs
Outputs from Immunogenetics
#350
of 1,215 outputs
Outputs of similar age
#9,363
of 28,362 outputs
Outputs of similar age from Immunogenetics
#4
of 11 outputs
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