Title |
Mesenchymal Chondrosarcoma: a Review with Emphasis on its Fusion-Driven Biology
|
---|---|
Published in |
Current Oncology Reports, March 2018
|
DOI | 10.1007/s11912-018-0668-z |
Pubmed ID | |
Authors |
Marc El Beaino, Jason Roszik, John A. Livingston, Wei-Lien Wang, Alexander J. Lazar, Behrang Amini, Vivek Subbiah, Valerae Lewis, Anthony P. Conley |
Abstract |
Mesenchymal chondrosarcoma is a rare but deadly form of chondrosarcoma that typically affects adolescents and young adults. While curative intent is possible for patients with localized disease, few options exist for patients in the unresectable/metastatic setting. Thus, it is imperative to understand the fusion-driven biology of this rare malignant neoplasm so as to lead to the future development of better therapeutics for this disease. This manuscript will briefly review the clinical and pathologic features of mesenchymal chondrosarcoma followed by an appraisal of existing data linked to the fusions, HEY1-NCOA2 and IRF2BP2-CDX1, and the associated downstream pathways. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 5 | 45% |
Brazil | 1 | 9% |
Spain | 1 | 9% |
Turkey | 1 | 9% |
Nigeria | 1 | 9% |
France | 1 | 9% |
Unknown | 1 | 9% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 7 | 64% |
Practitioners (doctors, other healthcare professionals) | 2 | 18% |
Science communicators (journalists, bloggers, editors) | 1 | 9% |
Scientists | 1 | 9% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 25 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 5 | 20% |
Student > Ph. D. Student | 3 | 12% |
Other | 2 | 8% |
Student > Doctoral Student | 1 | 4% |
Student > Master | 1 | 4% |
Other | 3 | 12% |
Unknown | 10 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 8 | 32% |
Biochemistry, Genetics and Molecular Biology | 4 | 16% |
Agricultural and Biological Sciences | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Unknown | 10 | 40% |