| Title |
Friedelane, isolated from Pouzolzia indica Gaud. exhibits toxic effect against melanoma
|
|---|---|
| Published in |
Methods in Cell Science, March 2018
|
| DOI | 10.1007/s10616-017-0174-4 |
| Pubmed ID | |
| Authors |
Debasish Maiti, Ashish Kumar Singha, Chaitali Sarkar, Soham Sarkar, Indrajit Sil Sarma, Kuntal Manna, Biswanath Dinda |
| Abstract |
Melanoma is a predominant cause of skin cancer-related deaths. It was reported that, the methanolic extract of Pouzolzia Indica (P. indica) on chromatography gave five compounds (1-hentriacontanyl palmitate, myricyl alcohol, 6,7-dimethoxycoumarin, trichadonic acid and friedelane), which inhibited the acute promyelocytic leukemia cell lines, NB4, and HT93A. Friedelane was extracted as active compound from methanolic extract of P. indica. In this study, friedelane was tested on murine metastatic B16F10 and B16BL6 melanoma cell lines. To achieve the target, the cell viability using trypan blue exclusion, acridine orange/EtBr staining and cell cytotoxicity were tested using MTT assay. Caspase-3, caspase-9, Cyt-c, BAD and Bax protein were assayed to evidence the apoptosis induction. The compound friedelane shows potent cytotoxic effect against metastatic melanoma mouse cell lines in 10 µg/ml concentration. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 8 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 8 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 38% |
| Student > Bachelor | 1 | 13% |
| Other | 1 | 13% |
| Researcher | 1 | 13% |
| Unknown | 2 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Arts and Humanities | 1 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 13% |
| Agricultural and Biological Sciences | 1 | 13% |
| Chemistry | 1 | 13% |
| Unknown | 4 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 March 2018.
All research outputs
#20,663,600
of 25,382,440 outputs
Outputs from Methods in Cell Science
#857
of 1,026 outputs
Outputs of similar age
#269,679
of 345,388 outputs
Outputs of similar age from Methods in Cell Science
#8
of 17 outputs
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