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Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial

Overview of attention for article published in International Journal of Cancer, February 2018
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Title
Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial
Published in
International Journal of Cancer, February 2018
DOI 10.1002/ijc.31271
Pubmed ID
Authors

Jiali Zheng, Anwar T. Merchant, Michael D. Wirth, Jiajia Zhang, Samuel O. Antwi, Azza Shoaibi, Nitin Shivappa, Rachael Z. Stolzenberg‐Solomon, James R. Hebert, Susan E. Steck

Abstract

Inflammation plays a central role in pancreatic cancer etiology and can be modulated by diet. We aimed to examine the association between the inflammatory potential of diet, assessed with the Dietary Inflammatory Index (DII®), and pancreatic cancer risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial prospective cohort. Our study included 101,449 participants aged 52 to 78 years at baseline who completed both baseline questionnaire and a diet history questionnaire. Energy-adjusted DII (E-DII) scores were computed based on food and supplement intake. Cox proportional hazards models and time dependent Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with participants in the lowest E-DII quintile (most anti-inflammatory scores) as referent. After a median 8.5 years of follow-up, 328 pancreatic cancer cases were identified. E-DII scores were not associated with pancreatic cancer risk in the multivariable model (HRQ5vsQ1 =0.94; 95% CI=0.66-1.35; P-trend=0.43). Time significantly modified the association (P-interaction=0.01). During follow up <4 years, there was suggestive evidence of an inverse association between E-DII and pancreatic cancer (HRQ5vsQ1 =0.60; 95% CI=0.35-1.02; P-trend=0.20) while there was a significant positive trend in the follow up ≥4 years (HRQ5vsQ1 =1.31; 95% CI=0.83-2.08; P-trend=0.03). Similar results were observed for E-DII from food only. Our study does not support an association between inflammatory potential of diet and pancreatic cancer risk; however, heterogeneous results were obtained with different follow-up times. These divergent associations may result from the influences of undetected disease in the short-term. This article is protected by copyright. All rights reserved.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 76 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 76 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 11 14%
Student > Master 8 11%
Professor 7 9%
Other 6 8%
Student > Ph. D. Student 5 7%
Other 10 13%
Unknown 29 38%
Readers by discipline Count As %
Medicine and Dentistry 21 28%
Nursing and Health Professions 10 13%
Business, Management and Accounting 2 3%
Social Sciences 2 3%
Agricultural and Biological Sciences 2 3%
Other 7 9%
Unknown 32 42%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 July 2018.
All research outputs
#19,869,877
of 24,417,958 outputs
Outputs from International Journal of Cancer
#10,739
of 12,063 outputs
Outputs of similar age
#338,593
of 447,694 outputs
Outputs of similar age from International Journal of Cancer
#78
of 110 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. This one is in the 10th percentile – i.e., 10% of other outputs scored the same or lower than it.
So far Altmetric has tracked 12,063 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 5th percentile – i.e., 5% of its peers scored the same or lower than it.
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We're also able to compare this research output to 110 others from the same source and published within six weeks on either side of this one. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.