| Title |
The effects of short-term sprint training on MCT expression in moderately endurance-trained runners
|
|---|---|
| Published in |
European Journal of Applied Physiology, January 2006
|
| DOI | 10.1007/s00421-005-0100-x |
| Pubmed ID | |
| Authors |
Dale C. Bickham, David J. Bentley, Peter F. Le Rossignol, David Cameron-Smith |
| Abstract |
The purpose of this study was to assess the effects of short-term sprint training on transient changes in monocarboxylate lactate transporter 1 (MCT1) and MCT4 protein and mRNA content. Seven moderately endurance-trained runners (mean +/- SE; age 27.7+/-2.9 years, body mass 81.1+/-5.9 kg, .VO(2max) 58.1+/-2.0 ml kg(-1) min(-1)) completed a .VO(2max) and a supramaximal running test to exhaustion (RTE) before and after a 6-week period of sprint training. The sprint training was progressive and consisted of 18 sessions of near maximal short duration (5-15 s) sprints to compliment the athlete's endurance training. Prior to the training period there was a significant (P<0.05) increase in MCT1, but not MCT4 protein, 2 h after the RTE. This occurred without any change in corresponding mRNA levels. After the training period, there was a significant increase in MCT1 protein but no significant change in the MCT4 isoform. Both MCT1 and MCT4 mRNA was significantly lower at rest and 2 h post-RTE after the completion of the training period. After the training period, there was a significant increase in the time to exhaustion and distance covered during the RTE. This study demonstrates that sprint training of this length and type results in an upregulation of MCT1 protein, but not MCT4 content. Additionally, this study shows conflicting adaptations in MCT1 and MCT4 protein and mRNA levels following training, which may indicate post-transcriptional regulation of MCT expression in human muscle. |
Mendeley readers
The data shown below were compiled from readership statistics for 108 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| France | 1 | <1% |
| Portugal | 1 | <1% |
| Denmark | 1 | <1% |
| Spain | 1 | <1% |
| Unknown | 102 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 19% |
| Student > Master | 18 | 17% |
| Student > Bachelor | 14 | 13% |
| Professor | 9 | 8% |
| Researcher | 7 | 6% |
| Other | 23 | 21% |
| Unknown | 16 | 15% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 50 | 46% |
| Agricultural and Biological Sciences | 11 | 10% |
| Biochemistry, Genetics and Molecular Biology | 8 | 7% |
| Medicine and Dentistry | 7 | 6% |
| Nursing and Health Professions | 4 | 4% |
| Other | 8 | 7% |
| Unknown | 20 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2007.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from European Journal of Applied Physiology
#2,159
of 4,345 outputs
Outputs of similar age
#44,816
of 172,799 outputs
Outputs of similar age from European Journal of Applied Physiology
#4
of 12 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 4,345 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.6. This one is in the 39th percentile – i.e., 39% of its peers scored the same or lower than it.
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We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.