| Title |
Macrophages, Wound Healing, and Fibrosis: Recent Insights
|
|---|---|
| Published in |
Current Rheumatology Reports, March 2018
|
| DOI | 10.1007/s11926-018-0725-5 |
| Pubmed ID | |
| Authors |
Kate S. Smigiel, William C. Parks |
| Abstract |
Macrophages are central players in the immune response following tissue injury. These cells perform many functions, and the changing tissue microenvironment during injury shapes macrophage phenotype down a variety of polarized pathways. This review summarizes the current knowledge on the roles of macrophages during different stages of tissue injury, repair, and-if repair is not achieved-fibrosis. Macrophages present early in inflammation are functionally distinct from those at later stages. The predominant macrophage phenotype must transition from pro-inflammatory to pro-reparative to facilitate wound healing and scar resolution. If macrophages fail to acquire a tissue-healing phenotype, dysregulated signals can be drivers of disease processes, such as sustained, exuberant inflammation-as occurs in arthropathies-and fibrosis. Comprehensive understanding of the roles of specific macrophage populations at different stages of the repair process will support the development of immune-targeted therapies for diseases such as fibrosis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 136 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 136 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 26 | 19% |
| Student > Bachelor | 22 | 16% |
| Student > Master | 18 | 13% |
| Student > Ph. D. Student | 11 | 8% |
| Student > Doctoral Student | 10 | 7% |
| Other | 13 | 10% |
| Unknown | 36 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 29 | 21% |
| Medicine and Dentistry | 20 | 15% |
| Immunology and Microbiology | 13 | 10% |
| Agricultural and Biological Sciences | 12 | 9% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 3% |
| Other | 17 | 13% |
| Unknown | 41 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 April 2018.
All research outputs
#17,937,475
of 23,031,582 outputs
Outputs from Current Rheumatology Reports
#545
of 718 outputs
Outputs of similar age
#260,938
of 359,614 outputs
Outputs of similar age from Current Rheumatology Reports
#15
of 26 outputs
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