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Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis

Overview of attention for article published in Neurobiology of Disease, December 2003
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Title
Overexpression of the chromosome 21 transcription factor Ets2 induces neuronal apoptosis
Published in
Neurobiology of Disease, December 2003
DOI 10.1016/s0969-9961(03)00107-4
Pubmed ID
Authors

E.J Wolvetang, O.M Bradfield, T Hatzistavrou, P.J Crack, J Busciglio, I Kola, P.J Hertzog

Abstract

Down syndrome (trisomy 21) neurons display an increased rate of apoptosis in vitro. The genes on chromosome 21 that mediate this increased cell death remain to be elucidated. Here we show that the chromosome 21 transcription factor Ets2, a gene that is overexpressed in Down syndrome, is expressed in neurons, and that moderate overexpression of Ets2 leads to increased apoptosis of primary neuronal cultures from Ets2 tg mice that involves activation of caspase-3. Our data therefore suggest that overexpression of ETS2 may contribute to the increased rate of apoptosis of neurons in Down syndrome.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 3%
United States 1 3%
Unknown 33 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 29%
Researcher 5 14%
Student > Master 5 14%
Student > Bachelor 3 9%
Student > Doctoral Student 2 6%
Other 6 17%
Unknown 4 11%
Readers by discipline Count As %
Agricultural and Biological Sciences 17 49%
Biochemistry, Genetics and Molecular Biology 4 11%
Medicine and Dentistry 4 11%
Neuroscience 3 9%
Psychology 1 3%
Other 0 0%
Unknown 6 17%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 December 2007.
All research outputs
#8,535,472
of 25,374,917 outputs
Outputs from Neurobiology of Disease
#1,777
of 3,389 outputs
Outputs of similar age
#36,085
of 142,653 outputs
Outputs of similar age from Neurobiology of Disease
#9
of 13 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,389 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.8. This one is in the 31st percentile – i.e., 31% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 142,653 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.