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Mendeley readers
Attention Score in Context
| Title |
A Novel Rab5 GDP/GTP Exchange Factor Complexed to Rabaptin-5 Links Nucleotide Exchange to Effector Recruitment and Function
|
|---|---|
| Published in |
Cell, September 1997
|
| DOI | 10.1016/s0092-8674(00)80380-3 |
| Pubmed ID | |
| Authors |
Hisanori Horiuchi, Roger Lippé, Heidi M. McBride, Mariantonietta Rubino, Philip Woodman, Harald Stenmark, Vladimir Rybin, Matthias Wilm, Keith Ashman, Matthias Mann, Marino Zerial |
| Abstract |
The small GTPase Rab5 plays an essential role in endocytic traffic. Rab GDP dissociation inhibitor delivers Rab5 to the membrane, where a nucleotide exchange activity allows recruitment of an effector protein, Rabaptin-5. Here we uncovered a novel 60 kDa Rab5-binding protein, Rabex-5. Rabex-5 forms a tight physical complex with Rabaptin-5, and this complex is essential for endocytic membrane fusion. Sequencing of mammalian Rabex-5 by nanoelectrospray mass spectrometry and cloning revealed striking homology to Vps9p, a yeast protein implicated in endocytic traffic. Rabex-5 displays GDP/GTP exchange activity on Rab5 upon delivery of the GTPase to the membrane. This demonstrates that a soluble exchange factor coupled to a Rab effector translocates from cytosol to the membrane, where the complex stabilizes the GTPase in the active state. |
Mendeley readers
The data shown below were compiled from readership statistics for 214 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Germany | 5 | 2% |
| United States | 4 | 2% |
| United Kingdom | 3 | 1% |
| Hungary | 2 | <1% |
| Canada | 1 | <1% |
| India | 1 | <1% |
| Unknown | 198 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 61 | 29% |
| Researcher | 38 | 18% |
| Student > Master | 19 | 9% |
| Professor | 15 | 7% |
| Student > Bachelor | 14 | 7% |
| Other | 40 | 19% |
| Unknown | 27 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 94 | 44% |
| Biochemistry, Genetics and Molecular Biology | 62 | 29% |
| Neuroscience | 8 | 4% |
| Chemistry | 4 | 2% |
| Immunology and Microbiology | 4 | 2% |
| Other | 12 | 6% |
| Unknown | 30 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2008.
All research outputs
#3,798,066
of 25,371,288 outputs
Outputs from Cell
#7,921
of 17,169 outputs
Outputs of similar age
#2,205
of 28,406 outputs
Outputs of similar age from Cell
#27
of 100 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 17,169 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 59.1. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 28,406 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 87% of its contemporaries.
We're also able to compare this research output to 100 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.