| Title |
Mechanisms of Trabecular Formation and Specification During Cardiogenesis
|
|---|---|
| Published in |
Pediatric Cardiology, March 2018
|
| DOI | 10.1007/s00246-018-1868-x |
| Pubmed ID | |
| Authors |
Mingfu Wu |
| Abstract |
Trabecular morphogenesis is a key morphologic event during cardiogenesis and contributes to the formation of a competent ventricular wall. Lack of trabeculation results in embryonic lethality. The trabecular morphogenesis is a multistep process that includes, but is not limited to, trabecular initiation, proliferation/growth, specification, and compaction. Although a number of signaling molecules have been implicated in regulating trabeculation, the cellular processes underlying mammalian trabecular formation are not fully understood. Recent works show that the myocardium displays polarity, and oriented cell division (OCD) and directional migration of the cardiomyocytes in the monolayer myocardium are required for trabecular initiation and formation. Furthermore, perpendicular OCD is an extrinsic asymmetric cell division that contributes to trabecular specification, and is a mechanism that causes the trabecular cardiomyocytes to be distinct from the cardiomyocytes in compact zone. Once the coronary vasculature system starts to function in the embryonic heart, the trabeculae will coalesce with the compact zone to thicken the heart wall, and abnormal compaction will lead to left ventricular non-compaction (LVNC) and heart failure. There are many reviews about compaction and LVNC. In this review, we will focus on the roles of myocardial polarity and OCD in trabecular initiation, formation, and specification. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 70 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 70 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 11 | 16% |
| Student > Bachelor | 11 | 16% |
| Student > Master | 11 | 16% |
| Researcher | 8 | 11% |
| Other | 2 | 3% |
| Other | 5 | 7% |
| Unknown | 22 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 22 | 31% |
| Medicine and Dentistry | 11 | 16% |
| Agricultural and Biological Sciences | 8 | 11% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
| Mathematics | 1 | 1% |
| Other | 5 | 7% |
| Unknown | 21 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2019.
All research outputs
#17,937,475
of 23,031,582 outputs
Outputs from Pediatric Cardiology
#808
of 1,414 outputs
Outputs of similar age
#239,669
of 329,889 outputs
Outputs of similar age from Pediatric Cardiology
#12
of 40 outputs
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We're also able to compare this research output to 40 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.