| Title |
Human INCENP colocalizes with the Aurora-B/AIRK2 kinase on chromosomes and is overexpressed in tumour cells
|
|---|---|
| Published in |
Chromosoma, May 2001
|
| DOI | 10.1007/s004120100130 |
| Pubmed ID | |
| Authors |
Richard R. Adams, Mark D. Eckley, Paola Vagnarelli, Sally P. Wheatley, Dietlind L. Gerloff, Alastair M. Mackay, Phyllis A. Svingen, Scott H. Kaufmann, William C. Earnshaw |
| Abstract |
The inner centromere protein (INCENP), which has previously been described in chicken, frog and mouse, is required for correct chromosome segregation and cytokinesis. We have identified the human INCENP gene by library screening and reverse transcription-polymerase chain reaction (RT-PCR) and localized it to chromosomal region 11q12. HsINCENP is a single-copy gene that consists of 17 exons and covers 25 kb of genomic DNA. The gene is expressed at highest levels in the colon, testis and prostate, consistent with its likely role in cell proliferation. HsINCENP encodes a highly basic protein of 915 amino acids that localizes to metaphase chromosomes and to the mitotic spindle and equatorial cortex at anaphase. Recently we showed that INCENP is stockpiled in a complex with the Aurora-B/XAIRK2 kinase in Xenopus eggs. Here we demonstrate that, consistent with such an interaction, the two proteins colocalize on human metaphase chromosomes. Levels of Aurora-B are increased in several human cancers, and we show here that HsINCENP protein levels are also significantly increased in several colorectal cancer cell lines. |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 36 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 13 | 36% |
| Student > Ph. D. Student | 5 | 14% |
| Professor > Associate Professor | 3 | 8% |
| Student > Bachelor | 2 | 6% |
| Professor | 2 | 6% |
| Other | 5 | 14% |
| Unknown | 6 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 14 | 39% |
| Agricultural and Biological Sciences | 11 | 31% |
| Medicine and Dentistry | 2 | 6% |
| Chemistry | 1 | 3% |
| Unknown | 8 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2023.
All research outputs
#3,799,086
of 25,374,917 outputs
Outputs from Chromosoma
#52
of 786 outputs
Outputs of similar age
#4,006
of 42,349 outputs
Outputs of similar age from Chromosoma
#1
of 3 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 786 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done particularly well, scoring higher than 92% of its peers.
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