| Title |
Significance of 11C-PIB PET/CT in cardiac amyloidosis compared with 99mTc-aprotinin scintigraphy: A pilot study
|
|---|---|
| Published in |
Journal of Nuclear Cardiology, March 2018
|
| DOI | 10.1007/s12350-018-1260-5 |
| Pubmed ID | |
| Authors |
Ryogo Minamimoto, Toru Awaya, Kentaro Iwama, Masatoshi Hotta, Kazuhiko Nakajima, Risen Hirai, Osamu Okazaki, Yukio Hiroi |
| Abstract |
This study was to investigate the significance of11C-Pittsburgh B (PIB) PET/CT in patients with suspected cardiac amyloidosis compared with99mTc-aprotinin scintigraphy. Thirteen consecutive patients with suspected cardiac amyloidosis were considered for enrolment in this prospective pilot study. Participants were scheduled to undergo a series of11C-PIB PET/CT and99mTc-aprotinin within a 2-month period. Finally, we evaluated nine cases who underwent both imaging modalities, and compared imaging results with clinical and pathological results and prognosis. Six of the 9 patients who underwent both imaging modalities were diagnosed with amyloidosis, of whom 3 patients were diagnosed with cardiac amyloidosis from endomyocardial biopsy. These 3 patients with positive11C-PIB uptake at the left ventricle wall showed worsening of cardiac function progressing in the short term or death caused by acute exacerbation of chronic heart failure. Six of 8 patients with positive uptake on99mTc-aprotinin presented with amyloid deposition in the left ventricle wall, but symptoms remained stable if results of11C-PIB were not positive. In a small sample of subjects, the present study showed that11C-PIB accumulation in myocardium indicated cardiac amyloidosis with poor prognosis. Uptake of11C-PIB may be related to progressive amyloid deposition to the heart and can predict patient prognosis. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 4 | 21% |
| Student > Ph. D. Student | 2 | 11% |
| Researcher | 2 | 11% |
| Student > Master | 1 | 5% |
| Lecturer | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 9 | 47% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 11 | 58% |
| Nursing and Health Professions | 1 | 5% |
| Biochemistry, Genetics and Molecular Biology | 1 | 5% |
| Unknown | 6 | 32% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 March 2018.
All research outputs
#17,302,400
of 25,394,764 outputs
Outputs from Journal of Nuclear Cardiology
#1,304
of 2,045 outputs
Outputs of similar age
#222,570
of 344,808 outputs
Outputs of similar age from Journal of Nuclear Cardiology
#16
of 30 outputs
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