| Title |
Fecal Microbiome Among Nursing Home Residents with Advanced Dementia and Clostridium difficile
|
|---|---|
| Published in |
Digestive Diseases and Sciences, March 2018
|
| DOI | 10.1007/s10620-018-5030-7 |
| Pubmed ID | |
| Authors |
Rafael Araos, Nikolaos Andreatos, Juan Ugalde, Susan Mitchell, Eleftherios Mylonakis, Erika M. C. D’Agata |
| Abstract |
Patients colonized with toxinogenic strains of Clostridium difficile have an increased risk of subsequent infection. Given the potential role of the gut microbiome in increasing the risk of C. difficile colonization, we assessed the diversity and composition of the gut microbiota among long-term care facility (LTCF) residents with advanced dementia colonized with C. difficile. Retrospective analysis of rectal samples collected during a prospective observational study. Thirty-five nursing homes in Boston, Massachusetts. Eighty-seven LTCF residents with advanced dementia. Operational taxonomic units were identified using 16S rRNA sequencing. Samples positive for C. difficile were matched to negative controls in a 1:3 ratio and assessed for differences in alpha diversity, beta diversity, and differentially abundant features. Clostridium difficile sequence variants were identified among 7/87 (8.04%) residents. No patient had evidence of C. difficile infection. Demographic characteristics and antimicrobial exposure were similar between the seven cases and 21 controls. The overall biodiversity among cases and controls was reduced with a median Shannon index of 3.2 (interquartile range 2.7-3.9), with no statistically significant differences between groups. The bacterial community structure was significantly different among residents with C. difficile colonization versus those without and included a predominance of Akkermansia spp., Dermabacter spp., Romboutsia spp., Meiothermus spp., Peptoclostridium spp., and Ruminococcaceae UGC 009. LTCF residents with advanced dementia have substantial dysbiosis of their gut microbiome. Specific taxa characterized C. difficile colonization status. |
X Demographics
The data shown below were collected from the profiles of 6 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| China | 1 | 17% |
| Austria | 1 | 17% |
| Unknown | 4 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 5 | 83% |
| Practitioners (doctors, other healthcare professionals) | 1 | 17% |
Mendeley readers
The data shown below were compiled from readership statistics for 100 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 100 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 14% |
| Researcher | 11 | 11% |
| Student > Master | 11 | 11% |
| Student > Bachelor | 10 | 10% |
| Student > Postgraduate | 5 | 5% |
| Other | 16 | 16% |
| Unknown | 33 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 13 | 13% |
| Agricultural and Biological Sciences | 9 | 9% |
| Neuroscience | 9 | 9% |
| Biochemistry, Genetics and Molecular Biology | 8 | 8% |
| Nursing and Health Professions | 7 | 7% |
| Other | 14 | 14% |
| Unknown | 40 | 40% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2018.
All research outputs
#3,591,132
of 24,885,505 outputs
Outputs from Digestive Diseases and Sciences
#461
of 4,561 outputs
Outputs of similar age
#69,870
of 335,052 outputs
Outputs of similar age from Digestive Diseases and Sciences
#11
of 80 outputs
Altmetric has tracked 24,885,505 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,561 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.9. This one has done well, scoring higher than 89% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,052 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 80 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 87% of its contemporaries.