| Title |
Dynamic regulation of nucleolar architecture
|
|---|---|
| Published in |
Current Opinion in Cell Biology, March 2018
|
| DOI | 10.1016/j.ceb.2018.02.013 |
| Pubmed ID | |
| Authors | |
| Abstract |
The nucleolus is the largest nuclear sub-compartment in which the early steps of ribosome biogenesis take place. It also plays an essential role in the assembly and function of non-ribosomal ribonucleoprotein (RNP) complexes, controls cell cycle progression and senses environmental stress. The spatial organization and dynamics of nucleolar proteins and RNA is regulated at different structural levels, which finally determine nucleolar architecture. The intimate link between nucleolar structure and function is reflected by transcription-dependent changes in nucleolus-associated chromatin, overall morphological alterations in response to external cues, and the liquid droplet-like behavior of nucleolar compartments. Here we provide a concise overview of the latest studies which integrate novel trends in nucleolar architecture research into the context of cell biology. |
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X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 156 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 34 | 22% |
| Researcher | 24 | 15% |
| Student > Master | 16 | 10% |
| Student > Bachelor | 14 | 9% |
| Student > Doctoral Student | 7 | 4% |
| Other | 23 | 15% |
| Unknown | 38 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 66 | 42% |
| Agricultural and Biological Sciences | 28 | 18% |
| Medicine and Dentistry | 8 | 5% |
| Computer Science | 4 | 3% |
| Immunology and Microbiology | 4 | 3% |
| Other | 6 | 4% |
| Unknown | 40 | 26% |