| Title |
DARPP-32 and NCS-1 Expression is not Altered in Brains of Rats Treated with Typical or Atypical Antipsychotics
|
|---|---|
| Published in |
Neurochemical Research, August 2007
|
| DOI | 10.1007/s11064-007-9470-2 |
| Pubmed ID | |
| Authors |
Bruno R. Souza, Bernardo S. Motta, Daniela V. F. Rosa, Karen C. L. Torres, Adalberto A. Castro, Clarissa M. Comim, André M. Sampaio, Fabrício F. Lima, Andreas Jeromin, João Quevedo, Marco A. Romano-Silva |
| Abstract |
Dopamine-mediated neurotransmission imbalances are associated with several psychiatry illnesses, such as schizophrenia. Recently it was demonstrated that two proteins involved in dopamine signaling are altered in prefrontal cortex (PFC) of schizophrenic patients. DARPP-32 is a key downstream effector of intracellular signaling pathway and is downregulated in PFC of schizophrenic subjects. NCS-1 is a neuronal calcium sensor that can inhibit dopamine receptor D2 internalization and is upregulated in PFC of schizophrenic subjects. It is well known that dopamine D2 receptor is the main target of antipsychotic. Therefore, our purpose was to study if chronic treatment with typical or atypical antipsychotics induced alterations in DARPP-32 and NCS-1 expression in five brain regions: prefrontal cortex, hippocampus, striatum, cortex and cerebellum. We did not find any changes in DARPP-32 and NCS-1 protein expression in any brain region investigated. |
Mendeley readers
The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| South Africa | 1 | 4% |
| Brazil | 1 | 4% |
| Unknown | 26 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 9 | 32% |
| Student > Ph. D. Student | 4 | 14% |
| Professor > Associate Professor | 3 | 11% |
| Student > Doctoral Student | 2 | 7% |
| Student > Bachelor | 2 | 7% |
| Other | 6 | 21% |
| Unknown | 2 | 7% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 9 | 32% |
| Neuroscience | 8 | 29% |
| Biochemistry, Genetics and Molecular Biology | 5 | 18% |
| Medicine and Dentistry | 3 | 11% |
| Nursing and Health Professions | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 1 | 4% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 September 2010.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Neurochemical Research
#588
of 2,095 outputs
Outputs of similar age
#24,760
of 68,820 outputs
Outputs of similar age from Neurochemical Research
#4
of 10 outputs
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