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Mendeley readers
Attention Score in Context
| Title |
Rab11‐FIP3 Is Critical for the Structural Integrity of the Endosomal Recycling Compartment
|
|---|---|
| Published in |
Traffic, March 2007
|
| DOI | 10.1111/j.1600-0854.2007.00543.x |
| Pubmed ID | |
| Authors |
Conor P. Horgan, Arkadiusz Oleksy, Alexander V. Zhdanov, Patrick Y. Lall, Ian J. White, Amir R. Khan, Clare E. Futter, John G. McCaffrey, Mary W. McCaffrey |
| Abstract |
Rab11-FIP3 is an endosomal recycling compartment (ERC) protein that is implicated in the process of membrane delivery from the ERC to sites of membrane insertion during cell division. Here we report that Rab11-FIP3 is critical for the structural integrity of the ERC during interphase. We demonstrate that knockdown of Rab11-FIP3 and expression of a mutant of Rab11-FIP3 that is Rab11-binding deficient cause loss of all ERC-marker protein staining from the pericentrosomal region of A431 cells. Furthermore, we find that fluorophore-labelled transferrin cannot access the pericentrosomal region of cells in which Rab11-FIP3 function has been perturbed. We find that this Rab11-FIP3 function appears to be specific because expression of the equivalent Rab11-binding deficient mutant of Rab-coupling protein does not perturb ERC morphology. In addition, we find that other organelles such as sorting and late endosomes are unaffected by loss of Rab11-FIP3 function. Finally, we demonstrate the presence of an extensive coiled-coil region between residues 463 and 692 of Rab11-FIP3, which exists as a dimer in solution and is critical to support its function on the ERC. Together, these data indicate that Rab11-FIP3 is necessary for the structural integrity of the pericentrosomal ERC. |
Mendeley readers
The data shown below were compiled from readership statistics for 79 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 1% |
| Spain | 1 | 1% |
| Germany | 1 | 1% |
| Ireland | 1 | 1% |
| Unknown | 75 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 29 | 37% |
| Researcher | 16 | 20% |
| Professor | 5 | 6% |
| Professor > Associate Professor | 5 | 6% |
| Student > Bachelor | 3 | 4% |
| Other | 10 | 13% |
| Unknown | 11 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 44 | 56% |
| Biochemistry, Genetics and Molecular Biology | 11 | 14% |
| Immunology and Microbiology | 5 | 6% |
| Chemistry | 3 | 4% |
| Neuroscience | 2 | 3% |
| Other | 5 | 6% |
| Unknown | 9 | 11% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#5,446,994
of 25,374,917 outputs
Outputs from Traffic
#186
of 1,267 outputs
Outputs of similar age
#17,460
of 90,728 outputs
Outputs of similar age from Traffic
#2
of 12 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 75th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,267 research outputs from this source. They receive a mean Attention Score of 3.9. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 90,728 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.
We're also able to compare this research output to 12 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.