| Title |
Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View
|
|---|---|
| Published in |
Molecular Neurobiology, March 2018
|
| DOI | 10.1007/s12035-018-1025-9 |
| Pubmed ID | |
| Authors |
Alice Biosa, Tiago F. Outeiro, Luigi Bubacco, Marco Bisaglia |
| Abstract |
Type 2 diabetes mellitus (T2DM) is a metabolic disorder characterized by elevated concentrations of glucose in the blood. The chronic hyperglycemic state accounts for most of the vascular complications associated to the disease and the prevalent mechanism proposed is related to the glycating chemistry mediated by methylglyoxal (MG), which accumulates in T2DM. In recent years, a higher risk of Parkinson's disease (PD) onset in people affected by T2DM has become evident, but the molecular mechanisms underlying the interplay between T2DM and PD are still unknown. The oxidative chemistry of dopamine and its reactivity towards the protein α-Synuclein (aS) has been associated to the pathogenesis of PD. Recently, aS has also been described to interact with MG. Interestingly, MG and the dopamine oxidation products share both structural similarity and chemical reactivity. The ability of MG to spread over the site of its production and react with aS could represent the rationale to explain the higher incidence of PD in T2DM-affected people and may open opportunities for the development of novel strategies to antagonize the raise of PD. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 96 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 96 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 14% |
| Student > Master | 11 | 11% |
| Researcher | 7 | 7% |
| Student > Bachelor | 6 | 6% |
| Student > Doctoral Student | 6 | 6% |
| Other | 13 | 14% |
| Unknown | 40 | 42% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 17 | 18% |
| Biochemistry, Genetics and Molecular Biology | 12 | 13% |
| Pharmacology, Toxicology and Pharmaceutical Science | 5 | 5% |
| Medicine and Dentistry | 4 | 4% |
| Psychology | 3 | 3% |
| Other | 11 | 11% |
| Unknown | 44 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 April 2018.
All research outputs
#3,158,367
of 23,031,582 outputs
Outputs from Molecular Neurobiology
#607
of 3,489 outputs
Outputs of similar age
#67,156
of 329,889 outputs
Outputs of similar age from Molecular Neurobiology
#16
of 123 outputs
Altmetric has tracked 23,031,582 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,489 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 329,889 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 79% of its contemporaries.
We're also able to compare this research output to 123 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.