| Title |
A major site of expression of the ets transcription factor Elf5 is epithelia of exocrine glands
|
|---|---|
| Published in |
Histochemistry and Cell Biology, November 2004
|
| DOI | 10.1007/s00418-004-0713-x |
| Pubmed ID | |
| Authors |
Erika J. Lapinskas, Jodie Palmer, Sharon Ricardo, Paul J. Hertzog, Annet Hammacher, Melanie A. Pritchard |
| Abstract |
Elf5 belongs to the ets family of transcription factors and was cloned by homology in the DNA binding domain to the related, epithelial-specific ets factor, Elf3. Elf5 mRNA is expressed highly in normal tissue rich in secretory epithelial cells, including mammary gland, lung, kidney, prostate, salivary gland and stomach. The function of Elf5 and the cell types in which it is expressed remain uncharacterised. The presence of Elf5 mRNA in normal tissues, but absence in cancer tissues, may suggest a role for Elf5 in differentiation and development. We have generated a rabbit antiserum directed against a peptide in the Elf5 DNA-binding domain that is conserved between murine and human sequences. The antiserum specifically detects human and murine Elf5 proteins on western blots and shows specific staining on paraffin-embedded sections obtained from tissues including mammary gland, kidney, salivary gland and stomach. Epithelia from the bladder lining, lung and prostate did not stain for the presence of Elf5, though these organs express Elf5 mRNA. We show for the first time that Elf5 is primarily expressed in epithelial cells and is likely to be an epithelial-specific protein. The antiserum should prove useful in further analysis of the expression and function of Elf5. |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 11% |
| Unknown | 17 | 89% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 4 | 21% |
| Student > Bachelor | 3 | 16% |
| Student > Ph. D. Student | 2 | 11% |
| Student > Master | 2 | 11% |
| Professor > Associate Professor | 2 | 11% |
| Other | 2 | 11% |
| Unknown | 4 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 32% |
| Medicine and Dentistry | 3 | 16% |
| Biochemistry, Genetics and Molecular Biology | 2 | 11% |
| Environmental Science | 1 | 5% |
| Psychology | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 3 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 December 2007.
All research outputs
#8,064,660
of 24,217,893 outputs
Outputs from Histochemistry and Cell Biology
#247
of 926 outputs
Outputs of similar age
#21,439
of 64,960 outputs
Outputs of similar age from Histochemistry and Cell Biology
#2
of 7 outputs
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