| Title |
Golgi phosphoprotein 2 (GOLPH2/GP73/GOLM1) interacts with secretory clusterin
|
|---|---|
| Published in |
Molecular Biology Reports, September 2010
|
| DOI | 10.1007/s11033-010-0251-7 |
| Pubmed ID | |
| Authors |
Yan Zhou, Leike Li, Longbo Hu, Tao Peng |
| Abstract |
Golgi phosphoprotein 2 (GOLPH2/GP73/GOLM1), a type-II Golgi transmembrane protein of unknown function, is up-regulated in many cancers. Its Golgi luminal domain is potentially the major functional domain. The goal of this study is to identify the proteins interacting with GOLPH2. Using secretory GOLPH2 (sGOLPH2, amino acid residues 55-401) as bait, secretory clusterin (sCLU) was identified as one interacting candidate by yeast two-hybrid screening, and the coiled-coil domain of GOLPH2 was found to be sufficient for interaction with sCLU. The interaction between GOLPH2 and sCLU was confirmed intracellularly and extracellularly. The intracellular co-localization of GOLPH2 and sCLU in Golgi was also shown. These results can help in understanding the biological and pathological significance of GOLPH2. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 19% |
| Student > Master | 4 | 19% |
| Researcher | 3 | 14% |
| Professor | 2 | 10% |
| Student > Doctoral Student | 2 | 10% |
| Other | 2 | 10% |
| Unknown | 4 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 7 | 33% |
| Agricultural and Biological Sciences | 4 | 19% |
| Medicine and Dentistry | 2 | 10% |
| Materials Science | 2 | 10% |
| Neuroscience | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 19% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Molecular Biology Reports
#389
of 2,905 outputs
Outputs of similar age
#34,467
of 95,688 outputs
Outputs of similar age from Molecular Biology Reports
#4
of 17 outputs
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