| Title |
Organization and expression of the SLC36 cluster of amino acid transporter genes
|
|---|---|
| Published in |
Mammalian Genome, February 2004
|
| DOI | 10.1007/s00335-003-2319-3 |
| Pubmed ID | |
| Authors |
John R. Bermingham, Jamie Pennington |
| Abstract |
Three closely related genes encoding amino acid transport proteins are clustered on 5q32 in humans, and Chromosome (Chr) 11 in mice. The human SLC36A1 gene, which encodes the lysosomal amino acid transporter LYAAT1/PAT1, generates multiple alternative mRNAs, some of which encode truncated proteins. SLC36A1 is expressed in numerous tissues, whereas expression of SLC36A2, which encodes the glycine transporter tramdorinl/PAT2, is most abundant in kidney and muscle. Expression of a third gene, SLC36A3, is restricted to testis. Mouse Slc36a2 also is expressed in bone and fat tissue. Polymorphisms in human SLC36A2 exclude it as a candidate locus for a peripheral neuropathy that has been mapped to 5q31-33. SLC36A2 is a candidate gene for 5q-myelodysplastic syndrome, on the basis of its chromosomal location and its expression in bone. |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 9% |
| Unknown | 10 | 91% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 36% |
| Student > Ph. D. Student | 2 | 18% |
| Student > Master | 2 | 18% |
| Professor | 1 | 9% |
| Researcher | 1 | 9% |
| Other | 0 | 0% |
| Unknown | 1 | 9% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 6 | 55% |
| Biochemistry, Genetics and Molecular Biology | 1 | 9% |
| Neuroscience | 1 | 9% |
| Medicine and Dentistry | 1 | 9% |
| Unknown | 2 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2020.
All research outputs
#7,454,066
of 22,788,370 outputs
Outputs from Mammalian Genome
#318
of 1,126 outputs
Outputs of similar age
#33,807
of 133,386 outputs
Outputs of similar age from Mammalian Genome
#3
of 7 outputs
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