| Title |
Collapsin response mediator protein-1: A novel invasion-suppressor gene
|
|---|---|
| Published in |
Clinical & Experimental Metastasis, February 2003
|
| DOI | 10.1023/a:1022598604565 |
| Pubmed ID | |
| Authors |
Jin-Yuan Shih, Yuan-Chii G. Lee, Shuenn-Chen Yang, Tse-Ming Hong, Chi-Ying F. Huang, Pan-Chyr Yang |
| Abstract |
Numerous genetic changes are associated with metastasis of cancer cells. Previously, we used microarray to identify that collapsin response mediator protein-1 (CRMP-1) was involved in cancer invasion and metastasis. We further characterized that CRMP-1 was a novel invasion-suppression gene. Members of the CRMP gene family are intracellular phosphoproteins involved in the mediation of semaphorin induced F-actin depolymerization and growth cone collapse. The precise mechanism by which CRMP-I inhibits invasion is not yet clear. However, CRMP-1 transfected cells had fewer filopodia and less Matrigel-invasion abilities. A low expression of CRMP-I mRNA in lung cancer tissue was significantly associated with advanced disease, lymph node metastasis, early post-operative relapse, and shorter survival. In this article, we reviewed the functions of CRMPs and semaphorins and analyzed the structure and motifs of CRMP-1 by bioinformatics. As such, we hoped to shed further light on the mechanism by which CRMP-1 suppresses the invasion of cancer cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 4% |
| Unknown | 25 | 96% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 5 | 19% |
| Student > Ph. D. Student | 5 | 19% |
| Researcher | 4 | 15% |
| Professor > Associate Professor | 3 | 12% |
| Student > Master | 3 | 12% |
| Other | 4 | 15% |
| Unknown | 2 | 8% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 10 | 38% |
| Medicine and Dentistry | 9 | 35% |
| Biochemistry, Genetics and Molecular Biology | 2 | 8% |
| Arts and Humanities | 1 | 4% |
| Immunology and Microbiology | 1 | 4% |
| Other | 1 | 4% |
| Unknown | 2 | 8% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 July 2018.
All research outputs
#8,533,995
of 25,371,288 outputs
Outputs from Clinical & Experimental Metastasis
#220
of 813 outputs
Outputs of similar age
#34,230
of 140,955 outputs
Outputs of similar age from Clinical & Experimental Metastasis
#4
of 12 outputs
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