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Mendeley readers
Attention Score in Context
| Title |
The neuronal repellent Slit inhibits leukocyte chemotaxis induced by chemotactic factors
|
|---|---|
| Published in |
Nature, April 2001
|
| DOI | 10.1038/35073616 |
| Pubmed ID | |
| Authors |
Jane Y. Wu, Lili Feng, Hwan-Tae Park, Necat Havlioglu, Leng Wen, Hao Tang, Kevin B. Bacon, Zhi-hong Jiang, Xiao-chun Zhang, Yi Rao |
| Abstract |
Migration is a basic feature of many cell types in a wide range of species. Since the 1800s, cell migration has been proposed to occur in the nervous and immune systems, and distinct molecular cues for mammalian neurons and leukocytes have been identified. Here we report that Slit, a secreted protein previously known for its role of repulsion in axon guidance and neuronal migration, can also inhibit leukocyte chemotaxis induced by chemotactic factors. Slit inhibition of the chemokine-induced chemotaxis can be reconstituted by the co-expression of a chemokine receptor containing seven transmembrane domains and Roundabout (Robo), a Slit receptor containing a single transmembrane domain. Thus, there is a functional interaction between single and seven transmembrane receptors. Our results reveal the activity of a neuronal guidance cue in regulating leukocyte migration and indicate that there may be a general conservation of guidance mechanisms underlying metazoan cell migration. In addition, we have uncovered an inhibitor of leukocyte chemotaxis, and propose a new therapeutic approach to treat diseases involving leukocyte migration and chemotactic factors. |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 2% |
| United Kingdom | 1 | <1% |
| France | 1 | <1% |
| China | 1 | <1% |
| Singapore | 1 | <1% |
| Unknown | 121 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 28 | 22% |
| Student > Ph. D. Student | 27 | 21% |
| Professor | 13 | 10% |
| Professor > Associate Professor | 11 | 9% |
| Student > Master | 8 | 6% |
| Other | 23 | 18% |
| Unknown | 17 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 48 | 38% |
| Biochemistry, Genetics and Molecular Biology | 20 | 16% |
| Medicine and Dentistry | 12 | 9% |
| Neuroscience | 7 | 6% |
| Immunology and Microbiology | 7 | 6% |
| Other | 10 | 8% |
| Unknown | 23 | 18% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 July 2023.
All research outputs
#4,764,956
of 23,053,169 outputs
Outputs from Nature
#55,892
of 91,436 outputs
Outputs of similar age
#6,513
of 41,033 outputs
Outputs of similar age from Nature
#187
of 400 outputs
Altmetric has tracked 23,053,169 research outputs across all sources so far. Compared to these this one has done well and is in the 76th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 91,436 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 99.6. This one is in the 35th percentile – i.e., 35% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 41,033 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 400 others from the same source and published within six weeks on either side of this one. This one is in the 46th percentile – i.e., 46% of its contemporaries scored the same or lower than it.