| Title |
Targeting NMDA receptors in stroke: new hope in neuroprotection
|
|---|---|
| Published in |
Molecular Brain, March 2018
|
| DOI | 10.1186/s13041-018-0357-8 |
| Pubmed ID | |
| Authors |
Qiu Jing Wu, Michael Tymianski |
| Abstract |
NMDA (N-methyl-d-aspartate) receptors (NMDARs) play a central role in excitotoxic neuronal death caused by ischemic stroke, but NMDAR channel blockers have failed to be translated into clinical stroke treatments. However, recent research on NMDAR-associated signaling complexes has identified important death-signaling pathways linked to NMDARs. This led to the generation of inhibitors that inhibit these pathways downstream from the receptor without necessarily blocking NMDARs. This therapeutic approach may have fewer side effects and/or provide a wider therapeutic window for stroke as compared to the receptor antagonists. In this review, we highlight the key findings in the signaling cascades downstream of NMDARs and the novel promising therapeutics for ischemic stroke. |
X Demographics
The data shown below were collected from the profiles of 4 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 25% |
| Unknown | 3 | 75% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 50% |
| Scientists | 1 | 25% |
| Members of the public | 1 | 25% |
Mendeley readers
The data shown below were compiled from readership statistics for 302 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 302 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 45 | 15% |
| Student > Ph. D. Student | 37 | 12% |
| Student > Master | 30 | 10% |
| Researcher | 26 | 9% |
| Other | 13 | 4% |
| Other | 47 | 16% |
| Unknown | 104 | 34% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 53 | 18% |
| Pharmacology, Toxicology and Pharmaceutical Science | 29 | 10% |
| Biochemistry, Genetics and Molecular Biology | 27 | 9% |
| Medicine and Dentistry | 27 | 9% |
| Agricultural and Biological Sciences | 19 | 6% |
| Other | 34 | 11% |
| Unknown | 113 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2021.
All research outputs
#13,071,847
of 22,780,165 outputs
Outputs from Molecular Brain
#437
of 1,106 outputs
Outputs of similar age
#164,603
of 332,785 outputs
Outputs of similar age from Molecular Brain
#11
of 19 outputs
Altmetric has tracked 22,780,165 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,106 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.1. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 332,785 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.