| Title |
Matriptase and its putative role in cancer
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, November 2006
|
| DOI | 10.1007/s00018-006-6298-x |
| Pubmed ID | |
| Authors |
K. Uhland |
| Abstract |
Tumor progression and metastasis are the pathologic effects of uncontrolled or deregulated invasive growth, a process in which proteases play a fundamental role. They mediate the degradation of extracellular matrix components and intercellular cohesive structures to allow migration of the cells into the extracellular environment and activate growth and angiogenic factors. In addition to metalloproteases and the plasminogen activation system, another protease, matriptase, contributes substantially to these processes. Matriptase is a type II transmembrane trypsin-like serine protease that is expressed by cells of epithelial origin and is overexpressed in a variety of human cancers. It has been suggested that this protease not only facilitates cellular invasiveness but may also activate oncogenic pathways. This review summarizes current knowledge about matriptase, its putative role in tumor initiation and progression, and its potential as a novel target in anti-cancer therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 109 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Australia | 1 | <1% |
| France | 1 | <1% |
| Finland | 1 | <1% |
| Denmark | 1 | <1% |
| Unknown | 103 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 25 | 23% |
| Researcher | 23 | 21% |
| Student > Bachelor | 13 | 12% |
| Student > Master | 11 | 10% |
| Professor | 4 | 4% |
| Other | 14 | 13% |
| Unknown | 19 | 17% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 34 | 31% |
| Biochemistry, Genetics and Molecular Biology | 19 | 17% |
| Chemistry | 11 | 10% |
| Medicine and Dentistry | 8 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 6% |
| Other | 8 | 7% |
| Unknown | 22 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 September 2023.
All research outputs
#3,460,684
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#571
of 4,151 outputs
Outputs of similar age
#12,953
of 159,308 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#5
of 34 outputs
Altmetric has tracked 23,794,258 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,151 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.0. This one has done well, scoring higher than 88% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 159,308 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 89% of its contemporaries.
We're also able to compare this research output to 34 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.