| Title |
1H, 13C and 15N backbone NMR chemical shift assignments of the C-terminal P4 domain of Ahnak
|
|---|---|
| Published in |
Biomolecular NMR Assignments, March 2018
|
| DOI | 10.1007/s12104-018-9818-3 |
| Pubmed ID | |
| Authors |
Srinivasan Sundararaj, Dmitry Shishmarev, Yiechang Lin, Shouvik Aditya, Marco G. Casarotto |
| Abstract |
Ahnak is a ~ 700 kDa polypeptide that was originally identified as a tumour-related nuclear phosphoprotein, but later recognized to play a variety of diverse physiological roles related to cell architecture and migration. A critical function of Ahnak is modulation of Ca2+ signaling in cardiomyocytes by interacting with the β subunit of the L-type Ca2+ channel (CaV1.2). Previous studies have identified the C-terminal region of Ahnak, designated as P3 and P4 domains, as a key mediator of its functional activity. We report here the nearly complete 1H, 13C and 15N backbone NMR chemical shift assignments of the 11 kDa C-terminal P4 domain of Ahnak. This study lays the foundations for future investigations of functional dynamics, structure determination and interaction site mapping of the CaV1.2-Ahnak complex. |
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 1 | 50% |
| Other | 1 | 50% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 1 | 50% |
| Social Sciences | 1 | 50% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 March 2018.
All research outputs
#18,594,219
of 23,031,582 outputs
Outputs from Biomolecular NMR Assignments
#136
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Outputs of similar age
#256,296
of 329,889 outputs
Outputs of similar age from Biomolecular NMR Assignments
#4
of 7 outputs
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